Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application

Astrid Pany, Marie Wohlgenannt, Safoura Klopprogge, Michael Wolzt, Thomas Heuser, Harald Kotisch, Claudia Valenta, Victoria Klang (Corresponding author)

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Abstract


Objective

The aim of the present study was to evaluate the effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set-up.
Methods

Formulation morphology was investigated using cryo-transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin-pH-Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels.
Results

Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations.
Conclusion

Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP-β-CD.
Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalInternational Journal of Cosmetic Science
Volume43
Issue number2
DOIs
Publication statusPublished - Apr 2021

Austrian Fields of Science 2012

  • 301208 Pharmaceutical technology

Keywords

  • &#8208
  • &#946
  • DELIVERY
  • DRUG
  • FORMULATIONS
  • LIPOSOMES
  • PENETRATION
  • PERMEATION
  • cyclodextrin
  • emulsions
  • hydroxypropyl&#8208
  • safety testing
  • skin barrier
  • submicron emulsion
  • submicron emulsion gel
  • hydroxypropyl-β-cyclodextrin

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