Effect of Rifampicin on the Distribution of [ 
            11 C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Martin Bauer; Alexander Traxl; Akihiro Matsuda; Rudolf Karch; Cécile Philippe; Lukas Nics; Eva-Maria Klebermass; Beatrix Wulkersdorfer; Maria Weber; Stefan Poschner; Nicolas Tournier; Walter Jäger; Wolfgang Wadsak; Marcus Hacker; Thomas Wanek; Markus Zeitlinger; Oliver Langer

doi:10.1021/acs.molpharmaceut.8b00588

Effect of Rifampicin on the Distribution of [ ¹¹ C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Martin Bauer, Alexander Traxl, Akihiro Matsuda, Rudolf Karch, Cécile Philippe, Lukas Nics, Eva-Maria Klebermass, Beatrix Wulkersdorfer, Maria Weber, Stefan Poschner, Nicolas Tournier, Walter Jäger, Wolfgang Wadsak, Marcus Hacker, Thomas Wanek, Markus Zeitlinger, Oliver Langer

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	4589-4598
Number of pages	10
Journal	Molecular Pharmaceutics
Volume	15
Issue number	10
DOIs	https://doi.org/10.1021/acs.molpharmaceut.8b00588
Publication status	Published - Oct 2018

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

CANCER RESISTANCE PROTEIN
DRUG DISPOSITION
EXPRESSION
HEPATIC-UPTAKE
HEPATOBILIARY TRANSPORT
INHIBITION
OATP2B1
PHARMACOKINETICS
ROSUVASTATIN
SUCCESSFUL PREDICTION
TRANSPORTING POLYPEPTIDES OATPS
[C-11]erlotinib
hepatocyte
liver
positron emission tomography
rifampicin
[ C]erlotinib

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10.1021/acs.molpharmaceut.8b00588

Cite this

Bauer, M., Traxl, A., Matsuda, A., Karch, R., Philippe, C., Nics, L., Klebermass, E.-M., Wulkersdorfer, B., Weber, M., Poschner, S., Tournier, N., Jäger, W., Wadsak, W., Hacker, M., Wanek, T., Zeitlinger, M., & Langer, O. (2018). Effect of Rifampicin on the Distribution of [ ¹¹ C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice. Molecular Pharmaceutics, 15(10), 4589-4598. https://doi.org/10.1021/acs.molpharmaceut.8b00588

@article{542886719adb4d9090c525f7e3df77ea,

title = "Effect of Rifampicin on the Distribution of [ 11 C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice",

keywords = "CANCER RESISTANCE PROTEIN, DRUG DISPOSITION, EXPRESSION, HEPATIC-UPTAKE, HEPATOBILIARY TRANSPORT, INHIBITION, OATP2B1, PHARMACOKINETICS, ROSUVASTATIN, SUCCESSFUL PREDICTION, TRANSPORTING POLYPEPTIDES OATPS, [C-11]erlotinib, hepatocyte, liver, positron emission tomography, rifampicin, [ C]erlotinib",

author = "Martin Bauer and Alexander Traxl and Akihiro Matsuda and Rudolf Karch and C{\'e}cile Philippe and Lukas Nics and Eva-Maria Klebermass and Beatrix Wulkersdorfer and Maria Weber and Stefan Poschner and Nicolas Tournier and Walter J{\"a}ger and Wolfgang Wadsak and Marcus Hacker and Thomas Wanek and Markus Zeitlinger and Oliver Langer",

year = "2018",

month = oct,

doi = "10.1021/acs.molpharmaceut.8b00588",

language = "English",

volume = "15",

pages = "4589--4598",

journal = "Molecular Pharmaceutics",

issn = "1543-8384",

publisher = "AMER CHEMICAL SOC",

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Bauer, M, Traxl, A, Matsuda, A, Karch, R , Philippe, C , Nics, L , Klebermass, E-M, Wulkersdorfer, B, Weber, M, Poschner, S, Tournier, N, Jäger, W, Wadsak, W, Hacker, M, Wanek, T, Zeitlinger, M & Langer, O 2018, 'Effect of Rifampicin on the Distribution of [ ¹¹ C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice', Molecular Pharmaceutics, vol. 15, no. 10, pp. 4589-4598. https://doi.org/10.1021/acs.molpharmaceut.8b00588

TY - JOUR

T1 - Effect of Rifampicin on the Distribution of [ 11 C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

AU - Bauer, Martin

AU - Traxl, Alexander

AU - Matsuda, Akihiro

AU - Karch, Rudolf

AU - Philippe, Cécile

AU - Nics, Lukas

AU - Klebermass, Eva-Maria

AU - Wulkersdorfer, Beatrix

AU - Weber, Maria

AU - Poschner, Stefan

AU - Tournier, Nicolas

AU - Jäger, Walter

AU - Wadsak, Wolfgang

AU - Hacker, Marcus

AU - Wanek, Thomas

AU - Zeitlinger, Markus

AU - Langer, Oliver

PY - 2018/10

Y1 - 2018/10

KW - CANCER RESISTANCE PROTEIN

KW - DRUG DISPOSITION

KW - EXPRESSION

KW - HEPATIC-UPTAKE

KW - HEPATOBILIARY TRANSPORT

KW - INHIBITION

KW - OATP2B1

KW - PHARMACOKINETICS

KW - ROSUVASTATIN

KW - SUCCESSFUL PREDICTION

KW - TRANSPORTING POLYPEPTIDES OATPS

KW - [C-11]erlotinib

KW - hepatocyte

KW - liver

KW - positron emission tomography

KW - rifampicin

KW - [ C]erlotinib

UR - http://www.scopus.com/inward/record.url?scp=85053637052&partnerID=8YFLogxK

U2 - 10.1021/acs.molpharmaceut.8b00588

DO - 10.1021/acs.molpharmaceut.8b00588

M3 - Article

C2 - 30180590

SN - 1543-8384

VL - 15

SP - 4589

EP - 4598

JO - Molecular Pharmaceutics

JF - Molecular Pharmaceutics

IS - 10

ER -

Effect of Rifampicin on the Distribution of [ 11 C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice

Austrian Fields of Science 2012

Keywords

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Effect of Rifampicin on the Distribution of [ ¹¹ C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice