Effects of dopamine and opioid receptor antagonism on the neural processing of social and nonsocial rewards

Claudia Massaccesi, Sebastian Korb, Sebastian Götzendorfer, Emilio Chiappini, Matthaeus Willeit, Johan N Lundström, Christian Windischberger, Christoph Eisenegger, Giorgia Silani

Publications: Contribution to journalArticlePeer Reviewed

Abstract

Rewards are a broad category of stimuli inducing approach behavior to aid survival. Extensive evidence from animal research has shown that wanting (the motivation to pursue a reward) and liking (the pleasure associated with its consumption) are mostly regulated by dopaminergic and opioidergic activity in dedicated brain areas. However, less is known about the neuroanatomy of dopaminergic and opioidergic regulation of reward processing in humans, especially when considering different types of rewards (i.e., social and nonsocial). To fill this gap of knowledge, we combined dopaminergic and opioidergic antagonism (via amisulpride and naltrexone administration) with functional neuroimaging to investigate the neurochemical and neuroanatomical bases of wanting and liking of matched nonsocial (food) and social (interpersonal touch) rewards, using a randomized, between-subject, placebo-controlled, double-blind design. While no drug effect was observed at the behavioral level, brain activity was modulated by the administered compounds. In particular, opioid antagonism, compared to placebo, reduced activity in the medial orbitofrontal cortex during consumption of the most valued social and nonsocial rewards. Dopamine antagonism, however, had no clear effects on brain activity in response to reward anticipation. These findings provide insights into the neurobiology of human reward processing and suggest a similar opioidergic regulation of the neural responses to social and nonsocial reward consumption.

Original languageEnglish
Article numbere26645
JournalHuman Brain Mapping
Volume45
Issue number4
DOIs
Publication statusPublished - 24 Mar 2024

Austrian Fields of Science 2012

  • 501001 General psychology
  • 106025 Neurobiology

Keywords

  • dopamine
  • fMRI
  • food
  • opioids
  • reward
  • social touch

Cite this