Endothelial Retargeting of AAV9 In Vivo

  • Tarik Bozoglu
  • , Seungmin Lee
  • , Tilman Ziegler
  • , Victoria Jurisch
  • , Sanne Maas
  • , Andrea Baehr
  • , Rabea Hinkel
  • , Amelie Hoenig
  • , Anjana Hariharan
  • , Christina Inyeop Kim
  • , Simon Decker
  • , Haider Sami
  • , Tobias Koppara
  • , Ruppert Oellinger
  • , Oliver J. Müller
  • , Derk Frank
  • , Remco Megens
  • , Peter Nelson
  • , Christian Weber
  • , Angelika Schnieke
  • Markus Sperandio, Gianluca Santamaria, Roland Rad, Alessandra Moretti, Karl Ludwig Laugwitz, Oliver Soehnlein, Manfred Ogris, Christian Kupatt

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Article number2103867
Number of pages12
JournalAdvanced Science
Volume9
Issue number7
DOIs
Publication statusPublished - 4 Mar 2022

Funding

T.B., S.L., and T.Z. contributed equally to this study. The authors wish to thank Cuong Kieu, Elisabeth Raatz, and Anja Wolf for expert technical assistance. This study was supported by the European Research Council (A.M., C.K.), the German Ministry for Education and Research (BMBF 01GU1105A to C.K.), the DZHK Large animal platform (to C.K.) and the German Research Foundation (DFG SFB‐TRR127‐A2 to A.B., C.K., SFB‐TRR 267‐B8 to A.S., C.K., and SFB1123‐A1, Z1, INST 409/150‐1 to C.W.). T.B., S.L., and T.Z. contributed equally to this study. The authors wish to thank Cuong Kieu, Elisabeth Raatz, and Anja Wolf for expert technical assistance. This study was supported by the European Research Council (A.M., C.K.), the German Ministry for Education and Research (BMBF 01GU1105A to C.K.), the DZHK Large animal platform (to C.K.) and the German Research Foundation (DFG SFB-TRR127-A2 to A.B., C.K., SFB-TRR 267-B8 to A.S., C.K., and SFB1123-A1, Z1, INST 409/150-1 to C.W.). Electron microscopy work was performed at the Core Facility Cell Imaging and Ultrastructure Research, University of Vienna- member of the Vienna Life-Science Instruments (VLSI) and the authors thank Norbert Cyran for the assistance.

Austrian Fields of Science 2012

  • 301207 Pharmaceutical chemistry

Keywords

  • endothelium
  • subject terms: gene therapy
  • vascular biology
  • SITE
  • subject terms
  • RECEPTOR
  • gene therapy
  • BLOOD-PRESSURE
  • DELIVERY
  • VECTOR
  • TRIAL
  • TROPISM
  • DISEASE
  • GENE-THERAPY
  • MICE
  • Blood Pressure
  • Endothelial Cells
  • Mice, Transgenic
  • Dependovirus/genetics
  • Animals
  • Swine
  • Mice
  • RNA, Guide

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