Essential Functional Interplay of the Catalytic Groups in Acid Phosphatase

Martin Pfeiffer, Rory M. Crean, Catia Moreira, Antonietta Parracino, Gustav Oberdorfer, Lothar Brecker, Friedrich Hammerschmidt, Shina Caroline Lynn Kamerlin (Corresponding author), Bernd Nidetzky (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)3357-3370
Number of pages14
JournalACS Catalysis
Volume12
Issue number6
DOIs
Publication statusPublished - 18 Mar 2022

Austrian Fields of Science 2012

  • 104015 Organic chemistry
  • 104008 Catalysis

Keywords

  • functional cooperativity
  • enzyme catalysis
  • EVB simulations
  • linear free-energy relationship
  • nucleophilic catalysis
  • phosphate transfer
  • PROTEIN-TYROSINE-PHOSPHATASE
  • COLI ALKALINE-PHOSPHATASE
  • SITE-DIRECTED MUTAGENESIS
  • PHOSPHORYL-TRANSFER
  • TRANSITION-STATE
  • BETA-PHOSPHOGLUCOMUTASE
  • ACTIVE-SITE
  • STEREOCHEMICAL COURSE
  • FREE-ENERGY
  • ENZYME

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