Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function

Giorgia Del Favero; Lukas Janker; Benjamin Neuditschko; Julia Hohenbichler; Endre Kiss; Lydia Woelflingseder; Christopher Gerner; Doris Marko

doi:10.1007/s00204-021-03042-y

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function

Giorgia Del Favero (Corresponding author), Lukas Janker, Benjamin Neuditschko, Julia Hohenbichler, Endre Kiss, Lydia Woelflingseder, Christopher Gerner (Corresponding author), Doris Marko

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	2201–2221
Number of pages	21
Journal	Archives of Toxicology
Volume	95
Issue number	6
DOIs	https://doi.org/10.1007/s00204-021-03042-y
Publication status	Published - 23 Apr 2021

Austrian Fields of Science 2012

106037 Proteomics
301211 Toxicology

Keywords

Deoxynivalenol dermotoxicity
Skin barrier
Unfolded protein response mitochondrial
Klf4 transcription factor

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https://phaidra.univie.ac.at/o:1535961Licence: CC BY 4.0

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Del Favero, G., Janker, L., Neuditschko, B., Hohenbichler, J., Kiss, E., Woelflingseder, L., Gerner, C., & Marko, D. (2021). Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. Archives of Toxicology, 95(6), 2201–2221. https://doi.org/10.1007/s00204-021-03042-y

Del Favero, Giorgia ; Janker, Lukas ; Neuditschko, Benjamin et al. / Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. In: Archives of Toxicology. 2021 ; Vol. 95, No. 6. pp. 2201–2221.

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keywords = "Deoxynivalenol dermotoxicity, Skin barrier, Unfolded protein response mitochondrial, Klf4 transcription factor",

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Del Favero, G, Janker, L, Neuditschko, B, Hohenbichler, J, Kiss, E, Woelflingseder, L, Gerner, C & Marko, D 2021, 'Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function', Archives of Toxicology, vol. 95, no. 6, pp. 2201–2221. https://doi.org/10.1007/s00204-021-03042-y

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. / Del Favero, Giorgia (Corresponding author); Janker, Lukas; Neuditschko, Benjamin et al.
In: Archives of Toxicology, Vol. 95, No. 6, 23.04.2021, p. 2201–2221.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function

AU - Del Favero, Giorgia

AU - Janker, Lukas

AU - Neuditschko, Benjamin

AU - Hohenbichler, Julia

AU - Kiss, Endre

AU - Woelflingseder, Lydia

AU - Gerner, Christopher

AU - Marko, Doris

PY - 2021/4/23

Y1 - 2021/4/23

KW - Deoxynivalenol dermotoxicity

KW - Skin barrier

KW - Unfolded protein response mitochondrial

KW - Klf4 transcription factor

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U2 - 10.1007/s00204-021-03042-y

DO - 10.1007/s00204-021-03042-y

M3 - Article

SN - 0340-5761

VL - 95

SP - 2201

EP - 2221

JO - Archives of Toxicology

JF - Archives of Toxicology

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Del Favero G, Janker L, Neuditschko B, Hohenbichler J, Kiss E, Woelflingseder L et al. Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function. Archives of Toxicology. 2021 Apr 23;95(6):2201–2221. doi: 10.1007/s00204-021-03042-y

Exploring the dermotoxicity of the mycotoxin deoxynivalenol: combined morphologic and proteomic profiling of human epidermal cells reveals alteration of lipid biosynthesis machinery and membrane structural integrity relevant for skin barrier function

Austrian Fields of Science 2012

Keywords

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