Genome flux and stasis in a five millennium transect of European prehistory

Cristina Gamba; Eppie R. Jones; Matthew D. Teasdale; Russell L McLaughlin; Gloria Gonzalez-Fortes; Valeria Mattiangeli; László Domboróczki; Ivett Kővári; Ildikó Pap; Alexandra Anders; Alasdair Whittle; János Dani; Pál Raczky; Thomas F G Higham; Michael Hofreiter; Daniel G. Bradley; Ron Pinhasi

doi:10.1038/ncomms6257

Genome flux and stasis in a five millennium transect of European prehistory

Cristina Gamba, Eppie R. Jones, Matthew D. Teasdale, Russell L McLaughlin, Gloria Gonzalez-Fortes, Valeria Mattiangeli, László Domboróczki, Ivett Kővári, Ildikó Pap, Alexandra Anders, Alasdair Whittle, János Dani, Pál Raczky, Thomas F G Higham, Michael Hofreiter, Daniel G. Bradley, Ron Pinhasi

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (~22 × ) and seven to ~1 × coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.

Original language	English
Article number	5257
Pages (from-to)	5257
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms6257
Publication status	Published - 2014
Externally published	Yes

Austrian Fields of Science 2012

106018 Human biology

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http://adsabs.harvard.edu/abs/2014NatCo...5E5257G

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Gamba, C., Jones, E. R., Teasdale, M. D., McLaughlin, R. L., Gonzalez-Fortes, G., Mattiangeli, V., Domboróczki, L., Kővári, I., Pap, I., Anders, A., Whittle, A., Dani, J., Raczky, P., Higham, T. F. G., Hofreiter, M., Bradley, D. G., & Pinhasi, R. (2014). Genome flux and stasis in a five millennium transect of European prehistory. Nature Communications, 5, 5257. Article 5257. https://doi.org/10.1038/ncomms6257

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title = "Genome flux and stasis in a five millennium transect of European prehistory",

abstract = "The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (~22 × ) and seven to ~1 × coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.",

author = "Cristina Gamba and Jones, {Eppie R.} and Teasdale, {Matthew D.} and McLaughlin, {Russell L} and Gloria Gonzalez-Fortes and Valeria Mattiangeli and L{\'a}szl{\'o} Dombor{\'o}czki and Ivett K{\H o}v{\'a}ri and Ildik{\'o} Pap and Alexandra Anders and Alasdair Whittle and J{\'a}nos Dani and P{\'a}l Raczky and Higham, {Thomas F G} and Michael Hofreiter and Bradley, {Daniel G.} and Ron Pinhasi",

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Gamba, C, Jones, ER, Teasdale, MD, McLaughlin, RL, Gonzalez-Fortes, G, Mattiangeli, V, Domboróczki, L, Kővári, I, Pap, I, Anders, A, Whittle, A, Dani, J, Raczky, P, Higham, TFG, Hofreiter, M, Bradley, DG & Pinhasi, R 2014, 'Genome flux and stasis in a five millennium transect of European prehistory', Nature Communications, vol. 5, 5257, pp. 5257. https://doi.org/10.1038/ncomms6257

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AU - Gonzalez-Fortes, Gloria

AU - Mattiangeli, Valeria

AU - Domboróczki, László

AU - Kővári, Ivett

AU - Pap, Ildikó

AU - Anders, Alexandra

AU - Whittle, Alasdair

AU - Dani, János

AU - Raczky, Pál

AU - Higham, Thomas F G

AU - Hofreiter, Michael

AU - Bradley, Daniel G.

AU - Pinhasi, Ron

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Genome flux and stasis in a five millennium transect of European prehistory

Abstract

Austrian Fields of Science 2012

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