H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

Palwinder Singh; Amrinder Singh; Jagroop Kaur; Wolfgang Holzer

doi:10.1039/c3ra44776f

H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

Palwinder Singh (Corresponding author), Amrinder Singh, Jagroop Kaur, Wolfgang Holzer

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Glycosylation of nucleobases is achieved by heating metal free
aqueous solution of nucleobase and sugar. It seems that abstraction of
N9/N1 H by C10-OH promotes N9/N1(nucleobase)-C10 (sugar) covalent
bond formation.

Original language	English
Pages (from-to)	3158-3161
Number of pages	4
Journal	RSC Advances
Volume	4
Issue number	7
Early online date	27 Nov 2013
DOIs	https://doi.org/10.1039/c3ra44776f
Publication status	Published - 2014

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry
104013 Natural product chemistry

Keywords

PURINE NUCLEOSIDES
PRIMITIVE EARTH
FORMAMIDE
ADENINE
RIBOSE
EVOLUTION
ORIGIN
LIFE

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title = "H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis",

abstract = "Glycosylation of nucleobases is achieved by heating metal freeaqueous solution of nucleobase and sugar. It seems that abstraction ofN9/N1 H by C10-OH promotes N9/N1(nucleobase)-C10 (sugar) covalentbond formation.",

keywords = "PURINE NUCLEOSIDES, PRIMITIVE EARTH, FORMAMIDE, ADENINE, RIBOSE, EVOLUTION, ORIGIN, LIFE",

author = "Palwinder Singh and Amrinder Singh and Jagroop Kaur and Wolfgang Holzer",

year = "2014",

doi = "10.1039/c3ra44776f",

language = "English",

volume = "4",

pages = "3158--3161",

journal = "RSC Advances ",

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T1 - H-Bond activated glycosylation of nucleobases

T2 - implications for prebiotic nucleoside synthesis

AU - Singh, Palwinder

AU - Singh, Amrinder

AU - Kaur, Jagroop

AU - Holzer, Wolfgang

PY - 2014

Y1 - 2014

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AB - Glycosylation of nucleobases is achieved by heating metal freeaqueous solution of nucleobase and sugar. It seems that abstraction ofN9/N1 H by C10-OH promotes N9/N1(nucleobase)-C10 (sugar) covalentbond formation.

KW - PURINE NUCLEOSIDES

KW - PRIMITIVE EARTH

KW - FORMAMIDE

KW - ADENINE

KW - RIBOSE

KW - EVOLUTION

KW - ORIGIN

KW - LIFE

UR - http://www.scopus.com/inward/record.url?scp=84890672138&partnerID=8YFLogxK

U2 - 10.1039/c3ra44776f

DO - 10.1039/c3ra44776f

M3 - Article

SN - 2046-2069

VL - 4

SP - 3158

EP - 3161

JO - RSC Advances

JF - RSC Advances

IS - 7

ER -

H-Bond activated glycosylation of nucleobases: implications for prebiotic nucleoside synthesis

Abstract

Austrian Fields of Science 2012

Keywords

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