High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones

Sonja Hager; Veronika F. S. Pape; Vivien Posa; Bianca Montsch; Lukas Uhlik; Gergely Szakacs; Szilard Toth; Nikolett Jabronka; Bernhard K. Keppler; Christian R. Kowol; Eva A. Enyedy; Petra Heffeter

doi:10.1089/ars.2019.7854

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones

Sonja Hager
, Veronika F. S. Pape
, Vivien Posa
, Bianca Montsch
, Lukas Uhlik
, Gergely Szakacs
, Szilard Toth
, Nikolett Jabronka
, Bernhard K. Keppler
, Christian R. Kowol
, Eva A. Enyedy (Corresponding author)
, Petra Heffeter (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	395-414
Number of pages	20
Journal	Antioxidants and Redox Signaling
Volume	33
Issue number	6
DOIs	https://doi.org/10.1089/ars.2019.7854
Publication status	Published - 9 Jun 2020

Funding

This work was supported by the National Research, Development and Innovation Office-NKFI through project FK 124240 and FIKP program TUDFO/47138-1/2019-ITM. Furthermore, this work was in part funded by the Austrian Science Fund (FWF) grant number P31923 (to C.R. Kowol and P. Heffeter) as well as by the bilateral program Scientific and Technological Cooperation of the OeAD. Part of the data was generated in course of the research exchange program Aktion ``Osterreich-Ungarn'' as well as in a short-term fellowship of the European Molecular Biology Organization (EMBO, grant ASTF335-2016) both to P. Heffeter. S. Hager is a recipient of a DOC Fellowship of the Austrian Academy of Sciences. The funding sources had no involvement in the collection, analysis, and interpretation of data as well as in the decision to submit the article for publication.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

302014 Endocrinology
301904 Cancer research
106002 Biochemistry
106023 Molecular biology

Keywords

solution stability
thiosemicarbazones
copper complexes
protein disulfide isomerase
paraptosis
superoxide dismutase
BIOLOGICAL EVALUATION
IN-VITRO
PHASE-I
TRIAPINE
IRON
DI-2-PYRIDYLKETONE
IDENTIFICATION
METABOLISM
STRESS
DP44MT

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10.1089/ars.2019.7854

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Hager, S., Pape, V. F. S., Posa, V., Montsch, B., Uhlik, L., Szakacs, G., Toth, S., Jabronka, N., Keppler, B. K., Kowol, C. R., Enyedy, E. A., & Heffeter, P. (2020). High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones. Antioxidants and Redox Signaling, 33(6), 395-414. https://doi.org/10.1089/ars.2019.7854

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title = "High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones",

keywords = "solution stability, thiosemicarbazones, copper complexes, protein disulfide isomerase, paraptosis, superoxide dismutase, BIOLOGICAL EVALUATION, IN-VITRO, PHASE-I, TRIAPINE, IRON, DI-2-PYRIDYLKETONE, IDENTIFICATION, METABOLISM, STRESS, DP44MT",

author = "Sonja Hager and Pape, \{Veronika F. S.\} and Vivien Posa and Bianca Montsch and Lukas Uhlik and Gergely Szakacs and Szilard Toth and Nikolett Jabronka and Keppler, \{Bernhard K.\} and Kowol, \{Christian R.\} and Enyedy, \{Eva A.\} and Petra Heffeter",

year = "2020",

month = jun,

day = "9",

doi = "10.1089/ars.2019.7854",

language = "English",

volume = "33",

pages = "395--414",

journal = "Antioxidants and Redox Signaling",

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Hager, S, Pape, VFS, Posa, V, Montsch, B, Uhlik, L, Szakacs, G, Toth, S, Jabronka, N, Keppler, BK , Kowol, CR, Enyedy, EA & Heffeter, P 2020, 'High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones', Antioxidants and Redox Signaling, vol. 33, no. 6, pp. 395-414. https://doi.org/10.1089/ars.2019.7854

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones. / Hager, Sonja; Pape, Veronika F. S.; Posa, Vivien et al.
In: Antioxidants and Redox Signaling, Vol. 33, No. 6, 09.06.2020, p. 395-414.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones

AU - Hager, Sonja

AU - Pape, Veronika F. S.

AU - Posa, Vivien

AU - Montsch, Bianca

AU - Uhlik, Lukas

AU - Szakacs, Gergely

AU - Toth, Szilard

AU - Jabronka, Nikolett

AU - Keppler, Bernhard K.

AU - Kowol, Christian R.

AU - Enyedy, Eva A.

AU - Heffeter, Petra

PY - 2020/6/9

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KW - thiosemicarbazones

KW - copper complexes

KW - protein disulfide isomerase

KW - paraptosis

KW - superoxide dismutase

KW - BIOLOGICAL EVALUATION

KW - IN-VITRO

KW - PHASE-I

KW - TRIAPINE

KW - IRON

KW - DI-2-PYRIDYLKETONE

KW - IDENTIFICATION

KW - METABOLISM

KW - STRESS

KW - DP44MT

UR - https://www.scopus.com/pages/publications/85088310141

U2 - 10.1089/ars.2019.7854

DO - 10.1089/ars.2019.7854

M3 - Article

SN - 1523-0864

VL - 33

SP - 395

EP - 414

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

IS - 6

ER -

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

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