Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Monika Malik; Raffaele Senatore; Davide Castiglione; Alexander Prado-Roller; Vittorio Pace

doi:10.1039/d3cc03326k

Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Monika Malik, Raffaele Senatore, Davide Castiglione, Alexander Prado-Roller, Vittorio Pace (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

α-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.

Original language	English
Pages (from-to)	11065-11068
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	74
DOIs	https://doi.org/10.1039/d3cc03326k
Publication status	Published - 21 Aug 2023

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

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10.1039/d3cc03326kLicence: CC BY 3.0

https://phaidra.univie.ac.at/o:2036110Licence: CC BY 3.0

Cite this

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AU - Malik, Monika

AU - Senatore, Raffaele

AU - Castiglione, Davide

AU - Prado-Roller, Alexander

AU - Pace, Vittorio

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PY - 2023/8/21

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AB - α-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.

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Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Abstract

Austrian Fields of Science 2012

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