Hohenheimer konsensusgesprach kupfer

Translated title of the contribution: Hohenheim consensus discussion on copper

K. Schümann, H. G. Classen, H. H. Dieter, J. König, G. Multhaup, M. Rükgauer, K. H. Summer, J. Bernhardt, H. K. Biesalski

Publications: Contribution to journalMeeting abstract/Conference paperPeer Reviewed

Abstract

Copper (Cu) is an essential trace element with many physiological functions. Homeostatic mechanisms exist to allow Cu to act as a cofactor in enzymatic processes and to prevent accumulation of Cu to toxic levels. The aim of this commentary is to better understand the role of dietary Cu supply in deficiency under physiological and pathological conditions. The essentiality of Cu can be attributed to its role as a cofactor in a number of enzymes that are involved in the defence of oxidative stress. Cu, however, has a second face, that of a toxic compound as it is observed with accumulating evidence in neurodegenerative and cardiovascular diseases. The destructive potential of Cu can be attributed to inherent properties. The main is its ability to take part in Fenton-like reactions in which the highly reactive and extremely deleterious hydroxyl radical is formed. Most likely, dietary Cu overload is based on a genetic predisposition. Thus, an assessment of risk-groups, such as infants with impaired mechanisms of Cu homeostasis regarding detoxification, is of special interest, as their Cu intake with resuspended formula milk may be considerably too high. This implies the need for reliable diagnostic markers to determine the Cu status. These topics were introduced at the workshop by all participants followed by extensive group discussion. The consensus statement was agreed on by all members. One of the conclusions is that a re-assessment of published data is necessary and future research is required.

Translated title of the contributionHohenheim consensus discussion on copper
Original languageGerman
Pages (from-to)283-296
Number of pages14
JournalAktuelle Ernahrungsmedizin
Volume24
Issue number6
Publication statusPublished - 1 Dec 1999
Externally publishedYes

Austrian Fields of Science 2012

  • 303009 Nutritional sciences

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