Hyperthermia-Induced Targeting of Thermosensitive Gene Carriers to Tumors

Funding

This work was funded by the Helmholtz Gemeinschaft (VH-VI-140, Clinical Hyperthermia and Related Technology), the "Forderprogramm fur Forschung und Lehre (Fo-FoLe)" of the medical faculty at the Ludwig-Maximilians University Munich, the Nanosystems Initiative Munich (NIM), and the European Community project "GIANT." The authors thank Prof. Mark Dewhirst for helpful discussions concerning the hyperthermia setup. Dr. Michael Gunther is gratefully acknowledged for help with semiquantitative analysis of Cy3 using ImageJ, Melinda Kiss for cryosectioning and staining of histological samples, and Olga Bruck for skilful assistance in preparing the manuscript.