TY - JOUR
T1 - Illuminating the Evolutionary History of Chlamydiae
AU - Horn, Matthias
AU - Horn, Astrid
AU - Schmitz-Esser, Stephan
AU - Beier, Cora L.
AU - Purkhold, Ulrike
AU - Fartmann, Berthold
AU - Brandt, Petra
AU - Nyakatura, Gerald
AU - Droege, Marcus
AU - Frishman, Dmitrij I.
AU - Rattei, Thomas
AU - Mewes, Hans Werner
AU - Wagner, Michael
N1 - Zeitschrift: Science
Coden: SCIEA
Affiliations: Department of Microbial Ecology, Inst. of Ecol. and Conserv. Biology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria; MWG Biotech AG, Anzinger Strasse 7a, 85560 Ebersberg, Germany; Dept. of Genome-Oriented Bioinfo., Tech. Universita?t Mu?nchen, Wissenschaftszentrum Weihenstephan, Am Forum 1, 85354 Freising, Germany
Adressen: Horn, M.; Department of Microbial Ecology; Inst. of Ecol. and Conserv. Biology; University of Vienna; Althanstrasse 14 1090 Vienna, Austria; email: [email protected]
Import aus Scopus: 2-s2.0-2342423344
24.08.2007: Datenanforderung 1832 (Import Sachbearbeiter)
PY - 2004
Y1 - 2004
N2 - Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.
AB - Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.
M3 - Article
VL - 304
SP - 728
EP - 730
JO - Science
JF - Science
SN - 0036-8075
IS - 5671
ER -
