Impact of P-glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans

Nicolas Tournier, Martin Bauer, Verena Pichler, Lukas Nics, Eva-Maria Klebermass, Karsten Bamminger, Peter Matzneller, Maria Weber, Rudolf Karch, Fabien Caille, Sylvain Auvity, Solene Marie, Walter Jaeger, Wolfgang Wadsak, Marcus Hacker, Markus Zeitlinger, Oliver Langer

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Pages (from-to)985-991
    Number of pages7
    JournalThe Journal of Nuclear Medicine
    Volume60
    Issue number7
    Early online date10 Jan 2019
    DOIs
    Publication statusPublished - 1 Jul 2019

    Austrian Fields of Science 2012

    • 301207 Pharmaceutical chemistry

    Keywords

    • ANTIEPILEPTIC DRUGS
    • ANTIPSYCHOTICS
    • BARRIER
    • C-11-metoclopramide
    • CANCER RESISTANCE PROTEIN
    • EFFLUX
    • INCREASES
    • INHIBITION
    • METABOLISM
    • MICE
    • P-glycoprotein
    • PET
    • TRANSPORT
    • blood-brain barrier
    • C-metoclopramide
    • Blood-brain barrier

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