Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

Verena Pichler; Simone Goeschl; Ekaterina Schreiber-Brynzak; Michael A. Jakupec; Mathea Sophia Galanski; Bernhard K. Keppler

doi:10.1039/c5mt00116a

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

Verena Pichler
, Simone Goeschl
, Ekaterina Schreiber-Brynzak
, Michael A. Jakupec (Corresponding author)
, Mathea Sophia Galanski
, Bernhard K. Keppler

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	1078-1090
Number of pages	13
Journal	Metallomics: integrated biometal science
Volume	7
Issue number	7
DOIs	https://doi.org/10.1039/c5mt00116a
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104003 Inorganic chemistry
106023 Molecular biology
106037 Proteomics

Keywords

CANCER-CELLS
REDUCTION
DNA
SATRAPLATIN
ASCORBATE
LIGANDS
PATHWAY
ANALOGS
BINDING

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10.1039/c5mt00116a

Cite this

Pichler, V., Goeschl, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M. S., & Keppler, B. K. (2015). Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines. Metallomics: integrated biometal science, 7(7), 1078-1090. https://doi.org/10.1039/c5mt00116a

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title = "Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines",

keywords = "CANCER-CELLS, REDUCTION, DNA, SATRAPLATIN, ASCORBATE, LIGANDS, PATHWAY, ANALOGS, BINDING",

author = "Verena Pichler and Simone Goeschl and Ekaterina Schreiber-Brynzak and Jakupec, \{Michael A.\} and Galanski, \{Mathea Sophia\} and Keppler, \{Bernhard K.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2015",

doi = "10.1039/c5mt00116a",

language = "English",

volume = "7",

pages = "1078--1090",

journal = "Metallomics: integrated biometal science",

issn = "1756-5901",

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Pichler, V, Goeschl, S, Schreiber-Brynzak, E, Jakupec, MA , Galanski, MS & Keppler, BK 2015, 'Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines', Metallomics: integrated biometal science, vol. 7, no. 7, pp. 1078-1090. https://doi.org/10.1039/c5mt00116a

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines. / Pichler, Verena; Goeschl, Simone; Schreiber-Brynzak, Ekaterina et al.
In: Metallomics: integrated biometal science, Vol. 7, No. 7, 2015, p. 1078-1090.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

AU - Pichler, Verena

AU - Goeschl, Simone

AU - Schreiber-Brynzak, Ekaterina

AU - Jakupec, Michael A.

AU - Galanski, Mathea Sophia

AU - Keppler, Bernhard K.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015

Y1 - 2015

KW - CANCER-CELLS

KW - REDUCTION

KW - DNA

KW - SATRAPLATIN

KW - ASCORBATE

KW - LIGANDS

KW - PATHWAY

KW - ANALOGS

KW - BINDING

UR - https://www.scopus.com/pages/publications/84936871435

U2 - 10.1039/c5mt00116a

DO - 10.1039/c5mt00116a

M3 - Article

SN - 1756-5901

VL - 7

SP - 1078

EP - 1090

JO - Metallomics: integrated biometal science

JF - Metallomics: integrated biometal science

IS - 7

ER -

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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