TY - JOUR
T1 - Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis
AU - Kueng, Angelika
AU - Pieper, Thomas
AU - Keppler, Bernhard
N1 - Zeitschrift: Journal of Chromatography B: Biomedical Sciences and Applications
DOI: 10.1016/S0378-4347(01)00205-5
Coden: JCBBE
Affiliations: Institute of Inorganic Chemistry, University of Vienna, Waehringer Str. 42, A-1090 Vienna, Austria
Adressen: Keppler, B.K.; Institute of Inorganic Chemistry; University of Vienna; Waehringer Str. 42 A-1090 Vienna, Austria
Source-File: ChemieErgScopus.csv
Import aus Scopus: 2-s2.0-0035812217
Importdatum: 09.01.2007 14:12:55
12.02.2008: Datenanforderung 2112 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2001
Y1 - 2001
N2 - Ruthenium(III) complexes of the general formula HL[RuCl4L2], with two trans-standing heterocyclic ligands L bound to ruthenium via nitrogen, show remarkable activity in different tumor models. To obtain a deeper insight into the mode of action of this class of anticancer compounds, we investigated the interaction of HIm trans-[RuCl4(im)2] (im, imidazole) and HInd trans-[RuCl4(ind)2] (ind, indazole) with all four nucleoside monophosphates in buffered solution by means of capillary electrophoresis. A preference for GMP- and AMP-coordination was found. A decrease of the pH resulted in a significantly increased amount of bound nucleotide. This feature seems to be interesting with regard to the lower pH values in solid tumors. Π2001 Elsevier Science B.V.
AB - Ruthenium(III) complexes of the general formula HL[RuCl4L2], with two trans-standing heterocyclic ligands L bound to ruthenium via nitrogen, show remarkable activity in different tumor models. To obtain a deeper insight into the mode of action of this class of anticancer compounds, we investigated the interaction of HIm trans-[RuCl4(im)2] (im, imidazole) and HInd trans-[RuCl4(ind)2] (ind, indazole) with all four nucleoside monophosphates in buffered solution by means of capillary electrophoresis. A preference for GMP- and AMP-coordination was found. A decrease of the pH resulted in a significantly increased amount of bound nucleotide. This feature seems to be interesting with regard to the lower pH values in solid tumors. Π2001 Elsevier Science B.V.
U2 - 10.1016/S0378-4347(01)00205-5
DO - 10.1016/S0378-4347(01)00205-5
M3 - Article
SN - 1570-0232
VL - 759
SP - 81
EP - 89
JO - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
JF - Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
IS - 1
ER -