Isothiouronium-Mediated Conversion of Carboxylic Acids to Cyanomethyl Thioesters

Irmgard Tiefenbrunner, Bogdan R. Brutiu, Tobias Stopka, Nuno Maulide (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Abstract

We report the development of an isothiouronium salt as a reagent for the operationally simple synthesis of cyanomethyl thioesters with high functional group tolerance and avoiding the use of thiols. Additionally, we show that the products can be engaged in amide synthesis in either a two-step or one-pot fashion.

Original languageEnglish
Pages (from-to)3941-3944
Number of pages4
JournalJournal of Organic Chemistry
Volume88
Issue number6
DOIs
Publication statusPublished - 17 Mar 2023

Austrian Fields of Science 2012

  • 104015 Organic chemistry

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