L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization

V. Pichler; C. Vraka; N. Berroterán-Infante; A. Krcal; H. Eidherr; T. Traub-Weidinger; M. Hacker; M. Mitterhauser; W. Wadsak

doi:10.1016/j.apradiso.2018.08.021

L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization

V. Pichler (Corresponding author), C. Vraka, N. Berroterán-Infante, A. Krcal, H. Eidherr, T. Traub-Weidinger, M. Hacker, M. Mitterhauser, W. Wadsak

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl- ¹¹C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	Applied Radiation and Isotopes
Volume	141
DOIs	https://doi.org/10.1016/j.apradiso.2018.08.021
Publication status	Published - Nov 2018

Austrian Fields of Science 2012

104020 Radiochemistry

Keywords

Carbon-11
IODINATION
L-[S-methyl-C-11]methionine
PET-tracer
ROUTINE PRODUCTION
Radiopharmaceuticals
[C-11]MeI production
L-[S-methyl- C]methionine
[ C]MeI production

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10.1016/j.apradiso.2018.08.021

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title = "L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization",

abstract = "Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl- 11C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield. ",

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year = "2018",

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doi = "10.1016/j.apradiso.2018.08.021",

language = "English",

volume = "141",

pages = "107--111",

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T1 - L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization

AU - Pichler, V.

AU - Vraka, C.

AU - Berroterán-Infante, N.

AU - Krcal, A.

AU - Eidherr, H.

AU - Traub-Weidinger, T.

AU - Hacker, M.

AU - Mitterhauser, M.

AU - Wadsak, W.

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AB - Radiosynthetic optimization is crucial in routine PET production but is often neglected in literature. Small changes in the radiochemical procedure can increase the yield significantly and reduce time fluctuation within the synthetic procedure enabling better planning and product release on time. Therefore, a highly reproducible production method for L-[S-methyl- 11C]methionine is presented, which uses a fully automated GE TRACERlab FX C Pro synthesizer. Evolution of the synthetic procedure lead to a protocol with a nearly doubled absolute yield.

KW - Carbon-11

KW - IODINATION

KW - L-[S-methyl-C-11]methionine

KW - PET-tracer

KW - ROUTINE PRODUCTION

KW - Radiopharmaceuticals

KW - [C-11]MeI production

KW - L-[S-methyl- C]methionine

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DO - 10.1016/j.apradiso.2018.08.021

M3 - Article

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VL - 141

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EP - 111

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

L-[S-methyl-C-11]methionine - An example of radiosynthetic optimization

Abstract

Austrian Fields of Science 2012

Keywords

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