Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

Bernhard Englinger; Anna Laemmerer; Patrick Moser; Sebastian Kallus; Clemens Roehrl; Christine Pirker; Dina Baier; Thomas Mohr; Laura Niederstaetter; Samuel M. Meier-Menches; Christopher Gerner; Lisa Gabler; Johannes Gojo; Gerald Timelthaler; Julia Senkiv; Walter Jaeger; Christian R. Kowol; Petra Heffeter; Walter Berger

doi:10.1002/ijc.32924

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

Bernhard Englinger
, Anna Laemmerer
, Patrick Moser
, Sebastian Kallus
, Clemens Roehrl
, Christine Pirker
, Dina Baier
, Thomas Mohr
, Laura Niederstaetter
, Samuel M. Meier-Menches
, Christopher Gerner
, Lisa Gabler
, Johannes Gojo
, Gerald Timelthaler
, Julia Senkiv
, Walter Jaeger
, Christian R. Kowol
, Petra Heffeter
, Walter Berger (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	1680-1693
Number of pages	14
Journal	International Journal of Cancer
Volume	147
Issue number	6
DOIs	https://doi.org/10.1002/ijc.32924
Publication status	Published - 2 Mar 2020

Funding

We are indebted to Mira Stojanovic, Irene Herbacek and Gerhard Zeitler for competent technical assistance. This project was supported by the Austrian Science Fund (FWF; P30105 and P19920 to W.B., I4164 to J.G., P28853 to C.R.K) and by Herzfelder'sche Familienstiftung (to C.P.).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301904 Cancer research
104002 Analytical chemistry
301206 Pharmacology

Keywords

Ponatinib
lipid droplets
resistance
cancer
drug sequestration
BREAST-CANCER CELLS
ACCUMULATION
ROLES

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10.1002/ijc.32924

Cite this

Englinger, B., Laemmerer, A., Moser, P., Kallus, S., Roehrl, C., Pirker, C., Baier, D., Mohr, T., Niederstaetter, L., Meier-Menches, S. M., Gerner, C., Gabler, L., Gojo, J., Timelthaler, G., Senkiv, J., Jaeger, W., Kowol, C. R., Heffeter, P., & Berger, W. (2020). Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib. International Journal of Cancer, 147(6), 1680-1693. https://doi.org/10.1002/ijc.32924

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title = "Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib",

keywords = "Ponatinib, lipid droplets, resistance, cancer, drug sequestration, BREAST-CANCER CELLS, ACCUMULATION, ROLES",

author = "Bernhard Englinger and Anna Laemmerer and Patrick Moser and Sebastian Kallus and Clemens Roehrl and Christine Pirker and Dina Baier and Thomas Mohr and Laura Niederstaetter and Meier-Menches, \{Samuel M.\} and Christopher Gerner and Lisa Gabler and Johannes Gojo and Gerald Timelthaler and Julia Senkiv and Walter Jaeger and Kowol, \{Christian R.\} and Petra Heffeter and Walter Berger",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. International Journal of Cancer published by John Wiley \& Sons Ltd on behalf of UICC",

year = "2020",

month = mar,

day = "2",

doi = "10.1002/ijc.32924",

language = "English",

volume = "147",

pages = "1680--1693",

journal = "International Journal of Cancer",

issn = "0020-7136",

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}

Englinger, B, Laemmerer, A, Moser, P, Kallus, S, Roehrl, C, Pirker, C, Baier, D, Mohr, T, Niederstaetter, L, Meier-Menches, SM , Gerner, C, Gabler, L, Gojo, J, Timelthaler, G, Senkiv, J, Jaeger, W , Kowol, CR, Heffeter, P & Berger, W 2020, 'Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib', International Journal of Cancer, vol. 147, no. 6, pp. 1680-1693. https://doi.org/10.1002/ijc.32924

TY - JOUR

T1 - Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

AU - Englinger, Bernhard

AU - Laemmerer, Anna

AU - Moser, Patrick

AU - Kallus, Sebastian

AU - Roehrl, Clemens

AU - Pirker, Christine

AU - Baier, Dina

AU - Mohr, Thomas

AU - Niederstaetter, Laura

AU - Meier-Menches, Samuel M.

AU - Gerner, Christopher

AU - Gabler, Lisa

AU - Gojo, Johannes

AU - Timelthaler, Gerald

AU - Senkiv, Julia

AU - Jaeger, Walter

AU - Kowol, Christian R.

AU - Heffeter, Petra

AU - Berger, Walter

PY - 2020/3/2

Y1 - 2020/3/2

KW - Ponatinib

KW - lipid droplets

KW - resistance

KW - cancer

KW - drug sequestration

KW - BREAST-CANCER CELLS

KW - ACCUMULATION

KW - ROLES

UR - https://www.scopus.com/pages/publications/85081268004

U2 - 10.1002/ijc.32924

DO - 10.1002/ijc.32924

M3 - Article

SN - 0020-7136

VL - 147

SP - 1680

EP - 1693

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 6

ER -

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib

Funding

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

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