Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Alexey A. Nazarov; Anton Legin; Michael Größl; Vladimir Arion; Michael Jakupec; Yury O. Tsybin; Paul J. Dyson; Bernhard Keppler; Christian Hartinger

doi:10.1039/c1cc14713g

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Alexey A. Nazarov, Anton Legin, Michael Größl, Vladimir Arion, Michael Jakupec, Yury O. Tsybin, Paul J. Dyson, Bernhard Keppler, Christian Hartinger (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

Original language	English
Pages (from-to)	1475-1477
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	10
DOIs	https://doi.org/10.1039/c1cc14713g
Publication status	Published - 2012

Austrian Fields of Science 2012

301206 Pharmacology
104003 Inorganic chemistry

Access to Document

10.1039/c1cc14713g

Cite this

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title = "Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules",

abstract = "Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.",

author = "Nazarov, {Alexey A.} and Anton Legin and Michael Gr{\"o}{\ss}l and Vladimir Arion and Michael Jakupec and Tsybin, {Yury O.} and Dyson, {Paul J.} and Bernhard Keppler and Christian Hartinger",

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AU - Nazarov, Alexey A.

AU - Legin, Anton

AU - Größl, Michael

AU - Arion, Vladimir

AU - Jakupec, Michael

AU - Tsybin, Yury O.

AU - Dyson, Paul J.

AU - Keppler, Bernhard

AU - Hartinger, Christian

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PY - 2012

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N2 - Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

AB - Ru(II)(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

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DO - 10.1039/c1cc14713g

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EP - 1477

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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