Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [11C]Tariquidar and PET in Humans and Mice

Irene Hernández Lozano, Martin Bauer, Beatrix Wulkersdorfer, Alexander Traxl, Cécile Philippe, Maria Weber, Stephanie Häusler, Bruno Stieger, Walter Jäger, Severin Mairinger, Thomas Wanek, Marcus Hacker, Markus Zeitlinger, Oliver Langer

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Pages (from-to)316-326
    Number of pages11
    JournalMolecular Pharmaceutics
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - 6 Jan 2020

    Austrian Fields of Science 2012

    • 301209 Pharmacy

    Keywords

    • ABCB1
    • ABCG2
    • BCRP/ABCG2
    • BLOOD-BRAIN-BARRIER
    • C-11-ELACRIDAR
    • C-11-TARIQUIDAR
    • CANCER RESISTANCE PROTEIN
    • CLEARANCE
    • HEPATOBILIARY TRANSPORT
    • P-GLYCOPROTEIN
    • PHARMACOKINETICS
    • TARIQUIDAR
    • [C-11]tariquidar
    • canalicular efflux transporter
    • liver
    • pharmacokinetic modeling
    • positron emission tomography
    • [ C]tariquidar

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