Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik Thanki; Delphine van Eetvelde; Antonia Geyer; Juan Fraire; Remi Hendrix; Hannelore Van Eygen; Emma Putteman; Haider Sami; Cristiane de Souza Carvalho-Wodarz; Henrik Franzyk; Hanne Mørck Nielsen; Kevin Braeckmans; Claus-Michael Lehr; Manfred Ogris; Camilla Foged

doi:10.1016/j.jconrel.2019.08.004

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik Thanki, Delphine van Eetvelde, Antonia Geyer, Juan Fraire, Remi Hendrix, Hannelore Van Eygen, Emma Putteman, Haider Sami, Cristiane de Souza Carvalho-Wodarz, Henrik Franzyk, Hanne Mørck Nielsen, Kevin Braeckmans, Claus-Michael Lehr, Manfred Ogris, Camilla Foged

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	82-93
Number of pages	12
Journal	Journal of Controlled Release
Volume	310
DOIs	https://doi.org/10.1016/j.jconrel.2019.08.004
Publication status	Published - 28 Sept 2019

Austrian Fields of Science 2012

210002 Nanobiotechnology
304004 Gene therapy
301206 Pharmacology

Keywords

CHALLENGES
DELIVERY
DRUG-RELEASE
Drug delivery
FLUORESCENCE
INTERFERENCE
Imaging
Lipid-polymer hybrid nanoparticles (LPNs)
Lipidoids
NUCLEIC-ACID
Nanomedicine
PLGA NANOPARTICLES
POLYPLEXES
Pulmonary administration
RNA
Release
SURFACTANT
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2019.08.004

Cite this

Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C.-M., Ogris, M., & Foged, C. (2019). Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. Journal of Controlled Release, 310, 82-93. https://doi.org/10.1016/j.jconrel.2019.08.004

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title = "Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration",

keywords = "CHALLENGES, DELIVERY, DRUG-RELEASE, Drug delivery, FLUORESCENCE, INTERFERENCE, Imaging, Lipid-polymer hybrid nanoparticles (LPNs), Lipidoids, NUCLEIC-ACID, Nanomedicine, PLGA NANOPARTICLES, POLYPLEXES, Pulmonary administration, RNA, Release, SURFACTANT, siRNA",

author = "Kaushik Thanki and {van Eetvelde}, Delphine and Antonia Geyer and Juan Fraire and Remi Hendrix and {Van Eygen}, Hannelore and Emma Putteman and Haider Sami and {de Souza Carvalho-Wodarz}, Cristiane and Henrik Franzyk and Nielsen, {Hanne M{\o}rck} and Kevin Braeckmans and Claus-Michael Lehr and Manfred Ogris and Camilla Foged",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = sep,

day = "28",

doi = "10.1016/j.jconrel.2019.08.004",

language = "English",

volume = "310",

pages = "82--93",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "ELSEVIER SCIENCE BV",

}

Thanki, K, van Eetvelde, D, Geyer, A, Fraire, J, Hendrix, R, Van Eygen, H, Putteman, E, Sami, H, de Souza Carvalho-Wodarz, C, Franzyk, H, Nielsen, HM, Braeckmans, K, Lehr, C-M, Ogris, M & Foged, C 2019, 'Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration', Journal of Controlled Release, vol. 310, pp. 82-93. https://doi.org/10.1016/j.jconrel.2019.08.004

TY - JOUR

T1 - Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

AU - Thanki, Kaushik

AU - van Eetvelde, Delphine

AU - Geyer, Antonia

AU - Fraire, Juan

AU - Hendrix, Remi

AU - Van Eygen, Hannelore

AU - Putteman, Emma

AU - Sami, Haider

AU - de Souza Carvalho-Wodarz, Cristiane

AU - Franzyk, Henrik

AU - Nielsen, Hanne Mørck

AU - Braeckmans, Kevin

AU - Lehr, Claus-Michael

AU - Ogris, Manfred

AU - Foged, Camilla

PY - 2019/9/28

Y1 - 2019/9/28

KW - CHALLENGES

KW - DELIVERY

KW - DRUG-RELEASE

KW - Drug delivery

KW - FLUORESCENCE

KW - INTERFERENCE

KW - Imaging

KW - Lipid-polymer hybrid nanoparticles (LPNs)

KW - Lipidoids

KW - NUCLEIC-ACID

KW - Nanomedicine

KW - PLGA NANOPARTICLES

KW - POLYPLEXES

KW - Pulmonary administration

KW - RNA

KW - Release

KW - SURFACTANT

KW - siRNA

UR - http://www.scopus.com/inward/record.url?scp=85070933691&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2019.08.004

DO - 10.1016/j.jconrel.2019.08.004

M3 - Article

C2 - 31398360

SN - 0168-3659

VL - 310

SP - 82

EP - 93

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Austrian Fields of Science 2012

Keywords

UN SDGs

Access to Document

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