Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik Thanki; Delphine van Eetvelde; Antonia Geyer; Juan Fraire; Remi Hendrix; Hannelore Van Eygen; Emma Putteman; Haider Sami; Cristiane de Souza Carvalho-Wodarz; Henrik Franzyk; Hanne Mørck Nielsen; Kevin Braeckmans; Claus-Michael Lehr; Manfred Ogris; Camilla Foged

doi:10.1016/j.jconrel.2019.08.004

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

Kaushik Thanki
, Delphine van Eetvelde
, Antonia Geyer
, Juan Fraire
, Remi Hendrix
, Hannelore Van Eygen
, Emma Putteman
, Haider Sami
, Cristiane de Souza Carvalho-Wodarz
, Henrik Franzyk
, Hanne Mørck Nielsen
, Kevin Braeckmans
, Claus-Michael Lehr
, Manfred Ogris
, Camilla Foged

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	82-93
Number of pages	12
Journal	Journal of Controlled Release
Volume	310
DOIs	https://doi.org/10.1016/j.jconrel.2019.08.004
Publication status	Published - 28 Sept 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

210002 Nanobiotechnology
304004 Gene therapy
301206 Pharmacology

Keywords

CHALLENGES
DELIVERY
DRUG-RELEASE
Drug delivery
FLUORESCENCE
INTERFERENCE
Imaging
Lipid-polymer hybrid nanoparticles (LPNs)
Lipidoids
NUCLEIC-ACID
Nanomedicine
PLGA NANOPARTICLES
POLYPLEXES
Pulmonary administration
RNA
Release
SURFACTANT
siRNA

Access to Document

10.1016/j.jconrel.2019.08.004

Cite this

Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, H., Nielsen, H. M., Braeckmans, K., Lehr, C.-M., Ogris, M., & Foged, C. (2019). Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration. Journal of Controlled Release, 310, 82-93. https://doi.org/10.1016/j.jconrel.2019.08.004

@article{02d8b25b7aab4f779fefe1b24abd35d2,

title = "Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration",

keywords = "CHALLENGES, DELIVERY, DRUG-RELEASE, Drug delivery, FLUORESCENCE, INTERFERENCE, Imaging, Lipid-polymer hybrid nanoparticles (LPNs), Lipidoids, NUCLEIC-ACID, Nanomedicine, PLGA NANOPARTICLES, POLYPLEXES, Pulmonary administration, RNA, Release, SURFACTANT, siRNA",

author = "Kaushik Thanki and \{van Eetvelde\}, Delphine and Antonia Geyer and Juan Fraire and Remi Hendrix and \{Van Eygen\}, Hannelore and Emma Putteman and Haider Sami and \{de Souza Carvalho-Wodarz\}, Cristiane and Henrik Franzyk and Nielsen, \{Hanne M{\o}rck\} and Kevin Braeckmans and Claus-Michael Lehr and Manfred Ogris and Camilla Foged",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = sep,

day = "28",

doi = "10.1016/j.jconrel.2019.08.004",

language = "English",

volume = "310",

pages = "82--93",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "ELSEVIER SCIENCE BV",

}

Thanki, K, van Eetvelde, D, Geyer, A, Fraire, J, Hendrix, R, Van Eygen, H, Putteman, E, Sami, H, de Souza Carvalho-Wodarz, C, Franzyk, H, Nielsen, HM, Braeckmans, K, Lehr, C-M, Ogris, M & Foged, C 2019, 'Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration', Journal of Controlled Release, vol. 310, pp. 82-93. https://doi.org/10.1016/j.jconrel.2019.08.004

TY - JOUR

T1 - Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

AU - Thanki, Kaushik

AU - van Eetvelde, Delphine

AU - Geyer, Antonia

AU - Fraire, Juan

AU - Hendrix, Remi

AU - Van Eygen, Hannelore

AU - Putteman, Emma

AU - Sami, Haider

AU - de Souza Carvalho-Wodarz, Cristiane

AU - Franzyk, Henrik

AU - Nielsen, Hanne Mørck

AU - Braeckmans, Kevin

AU - Lehr, Claus-Michael

AU - Ogris, Manfred

AU - Foged, Camilla

PY - 2019/9/28

Y1 - 2019/9/28

KW - CHALLENGES

KW - DELIVERY

KW - DRUG-RELEASE

KW - Drug delivery

KW - FLUORESCENCE

KW - INTERFERENCE

KW - Imaging

KW - Lipid-polymer hybrid nanoparticles (LPNs)

KW - Lipidoids

KW - NUCLEIC-ACID

KW - Nanomedicine

KW - PLGA NANOPARTICLES

KW - POLYPLEXES

KW - Pulmonary administration

KW - RNA

KW - Release

KW - SURFACTANT

KW - siRNA

UR - https://www.scopus.com/pages/publications/85070933691

U2 - 10.1016/j.jconrel.2019.08.004

DO - 10.1016/j.jconrel.2019.08.004

M3 - Article

C2 - 31398360

SN - 0168-3659

VL - 310

SP - 82

EP - 93

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

UN SDGs

Austrian Fields of Science 2012

Keywords

Access to Document

Other files and links

Fingerprint

Cite this