Metal-Free Intramolecular Alkyne-Azide Cycloaddition to Construct the Pyrazolo[4,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepine Ring System

Egle Arbačiauskiene; Vaida Laukaityte; Wolfgang Holzer; Algirdas Šačkus

doi:10.1002/ejoc.201500541

Metal-Free Intramolecular Alkyne-Azide Cycloaddition to Construct the Pyrazolo[4,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepine Ring System

Egle Arbačiauskiene, Vaida Laukaityte, Wolfgang Holzer, Algirdas Šačkus

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

A simple and efficient synthetic route to a new pyrazolo[4,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepine ring system has been developed by employing a metal-free, intramolecular alkyne-azide cycloaddition reaction as the key step. The structures of the obtained heterocyclic products were unequivocally confirmed by detailed ¹H, ¹³C, and ¹⁵N NMR spectroscopic experiments and single-crystal X-ray diffraction analysis.

Original language	English
Pages (from-to)	5663-5670
Number of pages	8
Journal	European Journal of Organic Chemistry
Volume	2015
Issue number	25
DOIs	https://doi.org/10.1002/ejoc.201500541
Publication status	Published - 1 Sept 2015

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

Alkynes
Azides
Cycloaddition
Fused-ring systems
Heterocycles

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10.1002/ejoc.201500541

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year = "2015",

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AU - Laukaityte, Vaida

AU - Holzer, Wolfgang

AU - Šačkus, Algirdas

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KW - Azides

KW - Cycloaddition

KW - Fused-ring systems

KW - Heterocycles

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Metal-Free Intramolecular Alkyne-Azide Cycloaddition to Construct the Pyrazolo[4,3-f][1,2,3]triazolo[5,1-c][1,4]oxazepine Ring System

Abstract

Austrian Fields of Science 2012

Keywords

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