Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Johanna P. van Geffen; Frauke Swieringa; Kim van Kuijk; Bibian M. E. Tullemans; Fiorella A. Solari; Bing Peng; Kenneth J. Clemetson; Richard W. Farndale; Ludwig J. Dubois; Albert Sickmann; Rene P. Zahedi; Robert Ahrends; Erik A. L. Biessen; Judith C. Sluimer; Johan W. M. Heemskerk; Marijke J. E. Kuijpers

doi:10.1038/s41598-020-78522-9

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Johanna P. van Geffen, Frauke Swieringa, Kim van Kuijk, Bibian M. E. Tullemans, Fiorella A. Solari, Bing Peng, Kenneth J. Clemetson, Richard W. Farndale, Ludwig J. Dubois, Albert Sickmann, Rene P. Zahedi, Robert Ahrends, Erik A. L. Biessen, Judith C. Sluimer, Johan W. M. Heemskerk, Marijke J. E. Kuijpers (Corresponding author)

Department of Analytical Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	21407
Number of pages	17
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-78522-9
Publication status	Published - 8 Dec 2020

Austrian Fields of Science 2012

301302 Lipidomics research
106037 Proteomics
104002 Analytical chemistry

Keywords

LOW-DENSITY-LIPOPROTEIN
PROCOAGULANT ACTIVITY
GLYCOPROTEIN-VI
HYPERCHOLESTEROLEMIA
ATHEROSCLEROSIS
KINASE
CHOLESTEROL
COAGULATION
ACTIVATION
INHIBITION

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://phaidra.univie.ac.at/o:1227578Licence: CC BY 4.0

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van Geffen, J. P., Swieringa, F., van Kuijk, K., Tullemans, B. M. E., Solari, F. A., Peng, B., Clemetson, K. J., Farndale, R. W., Dubois, L. J., Sickmann, A., Zahedi, R. P., Ahrends, R., Biessen, E. A. L., Sluimer, J. C., Heemskerk, J. W. M., & Kuijpers, M. J. E. (2020). Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome. Scientific Reports, 10(1), Article 21407. https://doi.org/10.1038/s41598-020-78522-9

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title = "Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome",

keywords = "LOW-DENSITY-LIPOPROTEIN, PROCOAGULANT ACTIVITY, GLYCOPROTEIN-VI, HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS, KINASE, CHOLESTEROL, COAGULATION, ACTIVATION, INHIBITION",

author = "{van Geffen}, {Johanna P.} and Frauke Swieringa and {van Kuijk}, Kim and Tullemans, {Bibian M. E.} and Solari, {Fiorella A.} and Bing Peng and Clemetson, {Kenneth J.} and Farndale, {Richard W.} and Dubois, {Ludwig J.} and Albert Sickmann and Zahedi, {Rene P.} and Robert Ahrends and Biessen, {Erik A. L.} and Sluimer, {Judith C.} and Heemskerk, {Johan W. M.} and Kuijpers, {Marijke J. E.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "8",

doi = "10.1038/s41598-020-78522-9",

language = "English",

volume = "10",

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issn = "2045-2322",

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van Geffen, JP, Swieringa, F, van Kuijk, K, Tullemans, BME, Solari, FA, Peng, B, Clemetson, KJ, Farndale, RW, Dubois, LJ, Sickmann, A, Zahedi, RP, Ahrends, R, Biessen, EAL, Sluimer, JC, Heemskerk, JWM & Kuijpers, MJE 2020, 'Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome', Scientific Reports, vol. 10, no. 1, 21407. https://doi.org/10.1038/s41598-020-78522-9

TY - JOUR

T1 - Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

AU - van Geffen, Johanna P.

AU - Swieringa, Frauke

AU - van Kuijk, Kim

AU - Tullemans, Bibian M. E.

AU - Solari, Fiorella A.

AU - Peng, Bing

AU - Clemetson, Kenneth J.

AU - Farndale, Richard W.

AU - Dubois, Ludwig J.

AU - Sickmann, Albert

AU - Zahedi, Rene P.

AU - Ahrends, Robert

AU - Biessen, Erik A. L.

AU - Sluimer, Judith C.

AU - Heemskerk, Johan W. M.

AU - Kuijpers, Marijke J. E.

PY - 2020/12/8

Y1 - 2020/12/8

KW - LOW-DENSITY-LIPOPROTEIN

KW - PROCOAGULANT ACTIVITY

KW - GLYCOPROTEIN-VI

KW - HYPERCHOLESTEROLEMIA

KW - ATHEROSCLEROSIS

KW - KINASE

KW - CHOLESTEROL

KW - COAGULATION

KW - ACTIVATION

KW - INHIBITION

UR - http://www.scopus.com/inward/record.url?scp=85097299507&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-78522-9

DO - 10.1038/s41598-020-78522-9

M3 - Article

SN - 2045-2322

VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 21407

ER -

Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome

Austrian Fields of Science 2012

Keywords

UN SDGs

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