Modular and Chemoselective Strategy for the Direct Access to α-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds

  • Serena Monticelli
  • , Marco Colella
  • , Veronica Pillari
  • , Arianna Tota
  • , Thierry Langer
  • , Wolfgang Holzer
  • , Leonardo Degennaro
  • , Renzo Luisi (Corresponding author)
  • , Vittorio Pace (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Original languageEnglish
Pages (from-to)584-588
Number of pages5
JournalOrganic Letters
Volume21
Issue number2
DOIs
Publication statusPublished - 18 Jan 2019

Funding

The authors thank the University of Vienna and Bari for financial support. This research was supported by the project Laboratorio Sistema code PONa300369 financed by MIUR, MISE, Horizon 2020 - PON 2014/2020 FARMIDIAB "code 338". S.M. acknowledges the University of Vienna for a Unidocs fellowship. We thank A. Roller and D. Dobusch (University of Vienna) for X-ray analysis and HRMS measurements, respectively. The authors are indebted to Albemarle Corporation and ABCR Germany for generous gifts of organolithiums and fluoroiodomethane. The authors thank the University of Vienna and Bari for financial support. This research was supported by the project Laboratorio Sistema code PONa300369 financed by MIUR, MISE, Horizon 2020 − PON 2014/2020 FARMIDIAB “code 338”. S.M. acknowledges the University of Vienna for a Unidocs fellowship. We thank A. Roller and D. Dobusch (University of Vienna) for X-ray analysis and HRMS measurements, respectively. The authors are indebted to Albemarle Corporation and ABCR Germany for generous gifts of organolithiums and fluoroiodomethane.

Austrian Fields of Science 2012

  • 104015 Organic chemistry

Keywords

  • NUCLEOPHILIC FLUOROMETHYLATION
  • STRAIGHTFORWARD ACCESS
  • EFFICIENT SYNTHESIS
  • FLUORINE
  • HOMOLOGATION
  • CARBENOIDS
  • STABILITY
  • MONOFLUOROMETHYLATION
  • FLUOROALKYLATION
  • EPOXIDATION

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