Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

Andreas Beier; Thomas C. Schwarz; Dennis Kurzbach; Gerald Platzer; Francesca Tribuzio; Robert Konrat

doi:10.1016/j.jmb.2018.04.035

Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

Andreas Beier
, Thomas C. Schwarz
, Dennis Kurzbach
, Gerald Platzer
, Francesca Tribuzio
, Robert Konrat (Corresponding author)

Max Perutz Labs

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	2439-2452
Number of pages	14
Journal	Journal of Molecular Biology
Volume	430
Issue number	16
DOIs	https://doi.org/10.1016/j.jmb.2018.04.035
Publication status	Published - 3 Aug 2018

Funding

A. Beier and G. Platzer were funded by the Christian Doppler Laboratory for High-Content Structural Biology and Biotechnology, Austria. The financial support by the Austrian Federal Ministry of Science, Research and Economy and the National Foundation for Research, Technology and Development is gratefully acknowledged.

Austrian Fields of Science 2012

106041 Structural biology

Keywords

IDP
NMR spectroscopy
protein complexes
synuclein
osteopontin
INTRINSICALLY DISORDERED PROTEINS
PARAMAGNETIC RELAXATION ENHANCEMENT
FAMILIAL PARKINSONS-DISEASE
NUCLEAR-MAGNETIC-RESONANCE
NMR DIPOLAR COUPLINGS
ALPHA-SYNUCLEIN
STRUCTURAL-CHARACTERIZATION
CHROMAFFIN CELLS
OSTEOPONTIN
CALMODULIN

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10.1016/j.jmb.2018.04.035

Cite this

@article{133b6e44cdc441749aed45e600d0ffec,

title = "Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism",

keywords = "IDP, NMR spectroscopy, protein complexes, synuclein, osteopontin, INTRINSICALLY DISORDERED PROTEINS, PARAMAGNETIC RELAXATION ENHANCEMENT, FAMILIAL PARKINSONS-DISEASE, NUCLEAR-MAGNETIC-RESONANCE, NMR DIPOLAR COUPLINGS, ALPHA-SYNUCLEIN, STRUCTURAL-CHARACTERIZATION, CHROMAFFIN CELLS, OSTEOPONTIN, CALMODULIN",

author = "Andreas Beier and Schwarz, \{Thomas C.\} and Dennis Kurzbach and Gerald Platzer and Francesca Tribuzio and Robert Konrat",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = aug,

day = "3",

doi = "10.1016/j.jmb.2018.04.035",

language = "English",

volume = "430",

pages = "2439--2452",

journal = "Journal of Molecular Biology",

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TY - JOUR

T1 - Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

AU - Beier, Andreas

AU - Schwarz, Thomas C.

AU - Kurzbach, Dennis

AU - Platzer, Gerald

AU - Tribuzio, Francesca

AU - Konrat, Robert

PY - 2018/8/3

Y1 - 2018/8/3

KW - IDP

KW - NMR spectroscopy

KW - protein complexes

KW - synuclein

KW - osteopontin

KW - INTRINSICALLY DISORDERED PROTEINS

KW - PARAMAGNETIC RELAXATION ENHANCEMENT

KW - FAMILIAL PARKINSONS-DISEASE

KW - NUCLEAR-MAGNETIC-RESONANCE

KW - NMR DIPOLAR COUPLINGS

KW - ALPHA-SYNUCLEIN

KW - STRUCTURAL-CHARACTERIZATION

KW - CHROMAFFIN CELLS

KW - OSTEOPONTIN

KW - CALMODULIN

UR - https://www.scopus.com/pages/publications/85047063824

U2 - 10.1016/j.jmb.2018.04.035

DO - 10.1016/j.jmb.2018.04.035

M3 - Article

SN - 0022-2836

VL - 430

SP - 2439

EP - 2452

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 16

ER -

Modulation of Correlated Segment Fluctuations in IDPs upon Complex Formation as an Allosteric Regulatory Mechanism

Funding

Austrian Fields of Science 2012

Keywords

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