Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors

Daniela Schuster; Mariana Spetea; Melisa Music; Silvia Rief; Monika Fink; Johannes Kirchmair; Johannes Schuetz; Gerhard Wolber; Thierry Langer; Hermann Stuppner; Helmut Schmidhammer; Judith M. Rollinger

doi:10.1016/j.bmc.2010.05.071

Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors

Daniela Schuster
, Mariana Spetea
, Melisa Music
, Silvia Rief
, Monika Fink
, Johannes Kirchmair
, Johannes Schuetz
, Gerhard Wolber
, Thierry Langer
, Hermann Stuppner
, Helmut Schmidhammer
, Judith M. Rollinger

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	5071-5080
Number of pages	10
Journal	Bioorganic & Medicinal Chemistry
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/j.bmc.2010.05.071
Publication status	Published - 15 Jul 2010
Externally published	Yes

Funding

This study was granted by the Austrian Research Promotion Agency (FFG, Bridge Project 810059). We acknowledge the technical assistance of Beatrix Jungwirth.

Austrian Fields of Science 2012

301207 Pharmaceutical chemistry

Keywords

Morphinans
Acetylcholinesterase inhibition
Opioid receptor
Pharmacophore modeling
LEAD STRUCTURE DISCOVERY
IN-SILICO PHARMACOLOGY
BIOLOGICAL EVALUATION
DRUG DISCOVERY
NATURAL-PRODUCTS
HIGHLY POTENT
14-ALKOXYMORPHINANS
AGONIST
DERIVATIVES
BINDING

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10.1016/j.bmc.2010.05.071

Cite this

Schuster, D., Spetea, M., Music, M., Rief, S., Fink, M., Kirchmair, J., Schuetz, J., Wolber, G., Langer, T., Stuppner, H., Schmidhammer, H., & Rollinger, J. M. (2010). Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. Bioorganic & Medicinal Chemistry, 18(14), 5071-5080. https://doi.org/10.1016/j.bmc.2010.05.071

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title = "Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors",

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author = "Daniela Schuster and Mariana Spetea and Melisa Music and Silvia Rief and Monika Fink and Johannes Kirchmair and Johannes Schuetz and Gerhard Wolber and Thierry Langer and Hermann Stuppner and Helmut Schmidhammer and Rollinger, \{Judith M.\}",

year = "2010",

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doi = "10.1016/j.bmc.2010.05.071",

language = "English",

volume = "18",

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journal = "Bioorganic \& Medicinal Chemistry",

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Schuster, D, Spetea, M, Music, M, Rief, S, Fink, M, Kirchmair, J, Schuetz, J, Wolber, G, Langer, T, Stuppner, H, Schmidhammer, H & Rollinger, JM 2010, 'Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors', Bioorganic & Medicinal Chemistry, vol. 18, no. 14, pp. 5071-5080. https://doi.org/10.1016/j.bmc.2010.05.071

TY - JOUR

T1 - Morphinans and isoquinolines

T2 - Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors

AU - Schuster, Daniela

AU - Spetea, Mariana

AU - Music, Melisa

AU - Rief, Silvia

AU - Fink, Monika

AU - Kirchmair, Johannes

AU - Schuetz, Johannes

AU - Wolber, Gerhard

AU - Langer, Thierry

AU - Stuppner, Hermann

AU - Schmidhammer, Helmut

AU - Rollinger, Judith M.

PY - 2010/7/15

Y1 - 2010/7/15

KW - Morphinans

KW - Acetylcholinesterase inhibition

KW - Opioid receptor

KW - Pharmacophore modeling

KW - LEAD STRUCTURE DISCOVERY

KW - IN-SILICO PHARMACOLOGY

KW - BIOLOGICAL EVALUATION

KW - DRUG DISCOVERY

KW - NATURAL-PRODUCTS

KW - HIGHLY POTENT

KW - 14-ALKOXYMORPHINANS

KW - AGONIST

KW - DERIVATIVES

KW - BINDING

U2 - 10.1016/j.bmc.2010.05.071

DO - 10.1016/j.bmc.2010.05.071

M3 - Article

SN - 0968-0896

VL - 18

SP - 5071

EP - 5080

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 14

ER -

Morphinans and isoquinolines: Acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors

Funding

Austrian Fields of Science 2012

Keywords

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