Abstract
Dermal delivery of peptides is a difficult task that needs to be solved by formulators in the pharmaceutical as well as in the cosmetic industry. Since multiple W/O/W emulsions are interesting vehicles for delivery of peptides, the influences of different plant-derived oils, namely avocado, wheatgerm and olive oil, on the formation and properties of multiple emulsions were investigated. The multiple W/O/W emulsions were characterized in terms of long-term stability, rheological properties, droplet size and internal structure. Moreover, the in vitro skin permeation of acetyl hexapeptide-8 (AH-8) from the multiple emulsions was investigated by Franz-type diffusion cells with porcine skin. The use of olive oil led to the most stable multiple emulsion with enhanced skin permeation of AH-8 compared to the other multiple emulsions. Moreover, a significantly increased skin permeation of AH-8 at acidic compared to physiological conditions revealed a strong dependency of AH-8 permeation on the chosen pH value.
Original language | English |
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Pages (from-to) | 16-22 |
Number of pages | 7 |
Journal | Journal of Drug Delivery Science and Technology |
Volume | 25 |
DOIs | |
Publication status | Published - 2015 |
Austrian Fields of Science 2012
- 301208 Pharmaceutical technology
Keywords
- Multiple emulsions
- Acetyl hexapeptide-8
- Franz-type diffusion cells
- Rheology
- Dermal peptide delivery
- Differential interference contrast microscopy
- Particle size analysis
- SKIN PERMEATION
- OIL
- RELEASE
- COSMECEUTICALS
- PENETRATION
- FORMULATION
- BARRIER
- PHASE
- Differential interference contrast
- Microscopy