Multiple W/O/W emulsions as dermal peptide delivery systems

Magdalena Hoppel, Sonja Juric, Gottfried Reznicek, Michael Wirth, Claudia Valenta

    Publications: Contribution to journalArticlePeer Reviewed

    Abstract

    Dermal delivery of peptides is a difficult task that needs to be solved by formulators in the pharmaceutical as well as in the cosmetic industry. Since multiple W/O/W emulsions are interesting vehicles for delivery of peptides, the influences of different plant-derived oils, namely avocado, wheatgerm and olive oil, on the formation and properties of multiple emulsions were investigated. The multiple W/O/W emulsions were characterized in terms of long-term stability, rheological properties, droplet size and internal structure. Moreover, the in vitro skin permeation of acetyl hexapeptide-8 (AH-8) from the multiple emulsions was investigated by Franz-type diffusion cells with porcine skin. The use of olive oil led to the most stable multiple emulsion with enhanced skin permeation of AH-8 compared to the other multiple emulsions. Moreover, a significantly increased skin permeation of AH-8 at acidic compared to physiological conditions revealed a strong dependency of AH-8 permeation on the chosen pH value.

    Original languageEnglish
    Pages (from-to)16-22
    Number of pages7
    JournalJournal of Drug Delivery Science and Technology
    Volume25
    DOIs
    Publication statusPublished - 2015

    Austrian Fields of Science 2012

    • 301208 Pharmaceutical technology

    Keywords

    • Multiple emulsions
    • Acetyl hexapeptide-8
    • Franz-type diffusion cells
    • Rheology
    • Dermal peptide delivery
    • Differential interference contrast microscopy
    • Particle size analysis
    • SKIN PERMEATION
    • OIL
    • RELEASE
    • COSMECEUTICALS
    • PENETRATION
    • FORMULATION
    • BARRIER
    • PHASE
    • Differential interference contrast
    • Microscopy

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