Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications

Haider Sami; Alexander Taschauer; Nathalie Tepe; Simon Decker; Norbert Cyran; Martina Anton; Thilo Hofmann; Andrey Rogach; Manfred Ogris

Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications

Haider Sami
, Alexander Taschauer
, Nathalie Tepe
, Simon Decker
, Norbert Cyran
, Martina Anton
, Thilo Hofmann
, Andrey Rogach
, Manfred Ogris

Publications: Contribution to conference › Other contribution to conference

Abstract

Introduction: Nanomedicine has significant potential for nucleic acid delivery and -therapy, but also faces challenges, both on the cellular level and in vivo [1]. Real-time tracking of nanocarriers in vivo can aid in identifying bot-tlenecks. The present work aims to address the above challenges by synthesizing polyplexes (complexes of nucleic acids with cationic poly-mers) functionalized with a) gold nanoparticles for small interfering RNA (siRNA) delivery (au-ropolyplexes; APxs) and b) quantum dots (QDs) for imageable gene delivery (quantopol-yplexes; QPxs).

Original language	German
Number of pages	1
Publication status	Published - 2019
Event	BioNanoMed 2019 - Nanotechnology enables Personalized Medicine - Graz, Austria Duration: 15 Apr 2019 → 17 Apr 2019

Conference

Conference	BioNanoMed 2019 - Nanotechnology enables Personalized Medicine
Abbreviated title	BioNanoMed
Country/Territory	Austria
City	Graz
Period	15/04/19 → 17/04/19

Austrian Fields of Science 2012

105906 Environmental geosciences

Cite this

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title = "Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications",

abstract = "Introduction: Nanomedicine has significant potential for nucleic acid delivery and -therapy, but also faces challenges, both on the cellular level and in vivo [1]. Real-time tracking of nanocarriers in vivo can aid in identifying bot-tlenecks. The present work aims to address the above challenges by synthesizing polyplexes (complexes of nucleic acids with cationic poly-mers) functionalized with a) gold nanoparticles for small interfering RNA (siRNA) delivery (au-ropolyplexes; APxs) and b) quantum dots (QDs) for imageable gene delivery (quantopol-yplexes; QPxs). ",

author = "Haider Sami and Alexander Taschauer and Nathalie Tepe and Simon Decker and Norbert Cyran and Martina Anton and Thilo Hofmann and Andrey Rogach and Manfred Ogris",

year = "2019",

language = "Deutsch",

note = "BioNanoMed 2019 - Nanotechnology enables Personalized Medicine, BioNanoMed ; Conference date: 15-04-2019 Through 17-04-2019",

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TY - CONF

T1 - Nanoparticle functionalized polyplexes: efficient nucleic acid delivery platform and theranostic applications

AU - Sami, Haider

AU - Taschauer, Alexander

AU - Tepe, Nathalie

AU - Decker, Simon

AU - Cyran, Norbert

AU - Anton, Martina

AU - Hofmann, Thilo

AU - Rogach, Andrey

AU - Ogris, Manfred

PY - 2019

Y1 - 2019

N2 - Introduction: Nanomedicine has significant potential for nucleic acid delivery and -therapy, but also faces challenges, both on the cellular level and in vivo [1]. Real-time tracking of nanocarriers in vivo can aid in identifying bot-tlenecks. The present work aims to address the above challenges by synthesizing polyplexes (complexes of nucleic acids with cationic poly-mers) functionalized with a) gold nanoparticles for small interfering RNA (siRNA) delivery (au-ropolyplexes; APxs) and b) quantum dots (QDs) for imageable gene delivery (quantopol-yplexes; QPxs).

AB - Introduction: Nanomedicine has significant potential for nucleic acid delivery and -therapy, but also faces challenges, both on the cellular level and in vivo [1]. Real-time tracking of nanocarriers in vivo can aid in identifying bot-tlenecks. The present work aims to address the above challenges by synthesizing polyplexes (complexes of nucleic acids with cationic poly-mers) functionalized with a) gold nanoparticles for small interfering RNA (siRNA) delivery (au-ropolyplexes; APxs) and b) quantum dots (QDs) for imageable gene delivery (quantopol-yplexes; QPxs).

M3 - Sonstiger Konferenzbeitrag

T2 - BioNanoMed 2019 - Nanotechnology enables Personalized Medicine

Y2 - 15 April 2019 through 17 April 2019

ER -