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Abstract
Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.
Original language | English |
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Article number | e202400167 |
Number of pages | 9 |
Journal | Helvetica Chimica Acta |
Volume | 108 |
Issue number | 2 |
Early online date | 25 Dec 2024 |
DOIs | |
Publication status | Published - Feb 2025 |
Austrian Fields of Science 2012
- 104017 Physical chemistry
- 104026 Spectroscopy
Keywords
- mass spectrometry
- molecular beams
- photocleavage
- physical chemistry
- synthetic chemistry
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ELUQUINT: Exploring the Limits of Universal Quantum Interferometry
1/12/21 → 1/12/26
Project: Research funding
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SuperMaMa: Superconducting Mass Spectrometry and Molecule Analysis
1/01/20 → 30/06/23
Project: Research funding