Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum

Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler (Corresponding author), Marcel Strauss, Martin F.X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Abstract

Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter-wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas-phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.
Original languageEnglish
Article numbere202400167
Number of pages9
JournalHelvetica Chimica Acta
Volume108
Issue number2
Early online date25 Dec 2024
DOIs
Publication statusPublished - Feb 2025

Austrian Fields of Science 2012

  • 104017 Physical chemistry
  • 104026 Spectroscopy

Keywords

  • mass spectrometry
  • molecular beams
  • photocleavage
  • physical chemistry
  • synthetic chemistry

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