TY - JOUR
T1 - New Iron(III)-Containing Composite of Salinomycinic Acid with Antitumor Activity—Synthesis and Characterization
AU - Ivanova, Juliana
AU - Kukeva, Rositsa
AU - Stoyanova, Radostina
AU - Zhivkova, Tanya
AU - Abudalleh, Abedulkadir
AU - Dyakova, Lora
AU - Alexandrova, Radostina
AU - Pashkunova-Martic, Irena
AU - Theiner, Johannes
AU - Dorkov, Peter
AU - Hejl, Michaela
AU - Jakupec, Michael A.
AU - Keppler, Bernhard
AU - Grabchev, Ivo
N1 - Publisher Copyright:
© 2024 by the authors.
Accession Number
WOS:001304680700001
PY - 2024/8
Y1 - 2024/8
N2 - In this study we demonstrated for the first time synthetic procedures for composites of salinomycin (SalH) and two-line ferrihydrite. The products were characterized by various methods such as elemental analysis, attenuated total reflectance–Fourier-transform spectroscopy (ATR-FTIR), electron paramagnetic resonance spectroscopy (EPR), powder X-ray diffraction analysis (XRD), electrospray-ionization mass spectrometry (ESI-MS), thermogravimetric analysis with differential thermal analysis (DTA) and mass spectrometry (TG-DTA/MS). The EPR spectra of the isolated compounds consisted of signals associated with both isolated Fe3+ ions and magnetically coupled Fe3+ ions. Powder XRD analyses of the isolated products showed two intense and broad peaks at 9° and 15° 2Θ, corresponding to salinomycinic acid. Broad peaks with very low intensity around 35°, assigned to two-line ferrihydrite, were also registered. Based on the experimental results, we concluded that salinomycin sodium reacted with Fe(III) chloride to form composites consisting of two-line ferrihydrite and salinomycinic acid. One of the composites exerted pronounced antitumor activity in the sub-micromolar concentration range against human cervical cancer (HeLa), non-small-cell lung cancer (A549), colon cancer (SW480), and ovarian teratocarcinoma (CH1/PA1) cells.
AB - In this study we demonstrated for the first time synthetic procedures for composites of salinomycin (SalH) and two-line ferrihydrite. The products were characterized by various methods such as elemental analysis, attenuated total reflectance–Fourier-transform spectroscopy (ATR-FTIR), electron paramagnetic resonance spectroscopy (EPR), powder X-ray diffraction analysis (XRD), electrospray-ionization mass spectrometry (ESI-MS), thermogravimetric analysis with differential thermal analysis (DTA) and mass spectrometry (TG-DTA/MS). The EPR spectra of the isolated compounds consisted of signals associated with both isolated Fe3+ ions and magnetically coupled Fe3+ ions. Powder XRD analyses of the isolated products showed two intense and broad peaks at 9° and 15° 2Θ, corresponding to salinomycinic acid. Broad peaks with very low intensity around 35°, assigned to two-line ferrihydrite, were also registered. Based on the experimental results, we concluded that salinomycin sodium reacted with Fe(III) chloride to form composites consisting of two-line ferrihydrite and salinomycinic acid. One of the composites exerted pronounced antitumor activity in the sub-micromolar concentration range against human cervical cancer (HeLa), non-small-cell lung cancer (A549), colon cancer (SW480), and ovarian teratocarcinoma (CH1/PA1) cells.
KW - ferrihydrite
KW - iron oxyhydroxides
KW - salinomycin
KW - theranostic agents
UR - http://www.scopus.com/inward/record.url?scp=85202621584&partnerID=8YFLogxK
U2 - 10.3390/inorganics12080206
DO - 10.3390/inorganics12080206
M3 - Article
AN - SCOPUS:85202621584
SN - 2304-6740
VL - 12
JO - Inorganics
JF - Inorganics
IS - 8
M1 - 206
ER -
