Obesity increases allergic airway inflammation that can be successfully treated by oral tolerance

The prevalence of obesity and allergy has increased in developed countries over the last decades,1, 2 leading to the hypothesis that these two noncommunicable diseases might be linked. It remains unclear whether obesity, characterized by chronic low-grade inflammation that affects host immunity, contributes to the exacerbation of respiratory allergies. Additionally, the efficacy of inducing mucosal tolerance as a prophylactic intervention against allergic airway disease in obese individuals is still a subject of inquiry. The impact of obesity on immune responses has been demonstrated in vaccinated individuals, revealing diminished vaccine efficacy and impaired duration of protection.3 Our current study investigates whether obesity could impact respiratory allergy development and the induction of mucosal allergen-specific tolerance.