Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods

Johanna Ungersböck, Cecile Philippe, Daniela Haeusler, Markus Mitterhauser, Rupert Lanzenberger, Robert Dudczak, Wolfgang Wadsak (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Abstract

The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).
Original languageEnglish
Pages (from-to)2615-2620
Number of pages6
JournalApplied Radiation and Isotopes
Volume70
Issue number11
DOIs
Publication statusPublished - 2012

Austrian Fields of Science 2012

  • 302054 Nuclear medicine
  • 104003 Inorganic chemistry

Fingerprint

Dive into the research topics of 'Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods'. Together they form a unique fingerprint.

Cite this