Abstract
The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).
Original language | English |
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Pages (from-to) | 2615-2620 |
Number of pages | 6 |
Journal | Applied Radiation and Isotopes |
Volume | 70 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2012 |
Austrian Fields of Science 2012
- 302054 Nuclear medicine
- 104003 Inorganic chemistry