Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods

Johanna Ungersböck; Cecile Philippe; Daniela Haeusler; Markus Mitterhauser; Rupert Lanzenberger; Robert Dudczak; Wolfgang Wadsak

doi:10.1016/j.apradiso.2012.08.001

Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods

Johanna Ungersböck
, Cecile Philippe
, Daniela Haeusler
, Markus Mitterhauser
, Rupert Lanzenberger
, Robert Dudczak
, Wolfgang Wadsak (Corresponding author)

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).

Original language	English
Pages (from-to)	2615-2620
Number of pages	6
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	11
DOIs	https://doi.org/10.1016/j.apradiso.2012.08.001
Publication status	Published - 2012

Austrian Fields of Science 2012

302054 Nuclear medicine
104003 Inorganic chemistry

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10.1016/j.apradiso.2012.08.001

Cite this

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title = "Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods",

abstract = "The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed {"}aging{"} effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6\% (EOB; 5.2 +/- 0.95 GBq EOS).",

author = "Johanna Ungersb{\"o}ck and Cecile Philippe and Daniela Haeusler and Markus Mitterhauser and Rupert Lanzenberger and Robert Dudczak and Wolfgang Wadsak",

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year = "2012",

doi = "10.1016/j.apradiso.2012.08.001",

language = "English",

volume = "70",

pages = "2615--2620",

journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods

AU - Ungersböck, Johanna

AU - Philippe, Cecile

AU - Haeusler, Daniela

AU - Mitterhauser, Markus

AU - Lanzenberger, Rupert

AU - Dudczak, Robert

AU - Wadsak, Wolfgang

N1 - Accession Number: WOS:000309787100010

PY - 2012

Y1 - 2012

N2 - The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).

AB - The intention for the present study was to implement a microfluidic set-up for N-C-11-methylations in a flow-through microreactor device with [C-11]DASB as model-compound and [C-11]CH3I and [C-11]CH3OTf, respectively, as C-11-methylation agents. Due to an observed "aging" effect of the C-11-methylation agents' solution, this goal was not achieved. Nevertheless, based on these observations, the time consumption for the vessel-based routine production of [C-11]DASB was reduced (34 +/- 1 min) and RCY was increased to 45.1 +/- 4.6% (EOB; 5.2 +/- 0.95 GBq EOS).

U2 - 10.1016/j.apradiso.2012.08.001

DO - 10.1016/j.apradiso.2012.08.001

M3 - Article

SN - 0969-8043

VL - 70

SP - 2615

EP - 2620

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 11

ER -

Optimization of [C-11]DASB-synthesis: Vessel-based and flow-through microreactor methods

Abstract

Austrian Fields of Science 2012

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