Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[(11)C]methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB)

Cecile Philippe, Daniela Haeusler, Markus Mitterhauser, Johanna Ungersböck, Helmut Viernstein, Robert Dudczak, Wolfgang Wadsak (Corresponding author)

Publications: Contribution to journalArticlePeer Reviewed

Abstract

[(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75 degrees C, 4 mg/mL precursor yielding at 48.0 +/- 2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183 +/- 14 GBq/mu mol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.
Original languageEnglish
Pages (from-to)1212-1217
Number of pages6
JournalApplied Radiation and Isotopes
Volume69
Issue number9
DOIs
Publication statusPublished - 2011

Austrian Fields of Science 2012

  • 301208 Pharmaceutical technology

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