TY - JOUR
T1 - Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[(11)C]methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB)
AU - Philippe, Cecile
AU - Haeusler, Daniela
AU - Mitterhauser, Markus
AU - Ungersböck, Johanna
AU - Viernstein, Helmut
AU - Dudczak, Robert
AU - Wadsak, Wolfgang
PY - 2011
Y1 - 2011
N2 - [(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75 degrees C, 4 mg/mL precursor yielding at 48.0 +/- 2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183 +/- 14 GBq/mu mol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.
AB - [(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75 degrees C, 4 mg/mL precursor yielding at 48.0 +/- 2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183 +/- 14 GBq/mu mol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.
U2 - 10.1016/j.apradiso.2011.04.010
DO - 10.1016/j.apradiso.2011.04.010
M3 - Article
SN - 0969-8043
VL - 69
SP - 1212
EP - 1217
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
IS - 9
ER -