OT6.231 - Towards Mass-Sensitive Assay Formats for Medical Drugs Using MIP Nanobodies

Solid-phase synthesis of molecularly imprinted polymers yields nanoparticles that inherently may re-place antibodies in bioassays. Herein, we demonstrate the approach for mass-sensitive detection of two medical drugs, namely salbutamol and vancomycin. While both yield appreciable sensor respons-es on quartz crystal microbalances – for salbutamol including a competitive assay, the responses to vancomycin are limited due to template size (and, thus, fewer binding events). One way to overcome this is to link the MIP nanoparticles to heavier particles to increase the response per binding event.