Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

Martin McLaughlin; Katharina Pallitsch; Gabriele Wallner; Wilfred A. van der Donk; Friedrich Hammerschmidt

doi:10.1021/acs.biochem.1c00113

Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

Martin McLaughlin, Katharina Pallitsch, Gabriele Wallner, Wilfred A. van der Donk (Corresponding author), Friedrich Hammerschmidt (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	1587-1596
Number of pages	10
Journal	Biochemistry
Volume	60
Issue number	20
DOIs	https://doi.org/10.1021/acs.biochem.1c00113
Publication status	Published - 25 May 2021

Funding

This study was supported by the National Institutes of Health (Grant P01 GM077596 to W.A.v.d.D.) and a National Science Foundation Graduate Research Fellowship (to M.I.M.). K.P. thanks the Austrian Science Fund (FWF) for financial support (P27987-N28). W.A.v.d.D. is an Investigator of the Howard Hughes Medical Institute.

Austrian Fields of Science 2012

106002 Biochemistry
106023 Molecular biology
104015 Organic chemistry

Keywords

S-ADENOSYLMETHIONINE METHYLASES
STREPTOMYCES-FRADIAE
NATURAL-PRODUCTS
CHIRAL ACETATES
C-METHYLATION
METHIONINE
MECHANISM
ACID
METHYLTRANSFERASE
INTERMEDIATE

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10.1021/acs.biochem.1c00113

Cite this

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title = "Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis",

keywords = "S-ADENOSYLMETHIONINE METHYLASES, STREPTOMYCES-FRADIAE, NATURAL-PRODUCTS, CHIRAL ACETATES, C-METHYLATION, METHIONINE, MECHANISM, ACID, METHYLTRANSFERASE, INTERMEDIATE",

author = "Martin McLaughlin and Katharina Pallitsch and Gabriele Wallner and \{van der Donk\}, \{Wilfred A.\} and Friedrich Hammerschmidt",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

year = "2021",

month = may,

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doi = "10.1021/acs.biochem.1c00113",

language = "English",

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T1 - Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

AU - McLaughlin, Martin

AU - Pallitsch, Katharina

AU - Wallner, Gabriele

AU - van der Donk, Wilfred A.

AU - Hammerschmidt, Friedrich

PY - 2021/5/25

Y1 - 2021/5/25

KW - S-ADENOSYLMETHIONINE METHYLASES

KW - STREPTOMYCES-FRADIAE

KW - NATURAL-PRODUCTS

KW - CHIRAL ACETATES

KW - C-METHYLATION

KW - METHIONINE

KW - MECHANISM

KW - ACID

KW - METHYLTRANSFERASE

KW - INTERMEDIATE

UR - https://www.scopus.com/pages/publications/85106387763

U2 - 10.1021/acs.biochem.1c00113

DO - 10.1021/acs.biochem.1c00113

M3 - Article

SN - 0006-2960

VL - 60

SP - 1587

EP - 1596

JO - Biochemistry

JF - Biochemistry

IS - 20

ER -

Overall Retention of Methyl Stereochemistry during B-12-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

Funding

Austrian Fields of Science 2012

Keywords

Access to Document

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