Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Brendan J Tunstall; Dean Kirson; Lia J Zallar; Sam A McConnell; Janaina C M Vendruscolo; Chelsea P Ho; Christopher S Oleata; Sophia Khom; Maurice Manning; Mary R Lee; Lorenzo Leggio; George F Koob; Marisa Roberto; Leandro F Vendruscolo

doi:10.1371/journal.pbio.2006421

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Brendan J Tunstall (Corresponding author)
, Dean Kirson
, Lia J Zallar
, Sam A McConnell
, Janaina C M Vendruscolo
, Chelsea P Ho
, Christopher S Oleata
, Sophia Khom
, Maurice Manning
, Mary R Lee
, Lorenzo Leggio
, George F Koob
, Marisa Roberto
, Leandro F Vendruscolo

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	e2006421
Number of pages	28
Journal	PLoS Biology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1371/journal.pbio.2006421
Publication status	Published - 16 Apr 2019
Externally published	Yes

Funding

National Institute on Drug Abuse-Intramural Research Program (grant number N/A) supported BJT, GFK, LFV. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Institutes of Health (grant number F32 AA02526) awarded to DK. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Institutes of Health (grant number AA015566) awarded to MR. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Institutes of Health (grant number AA017447) awarded to MR. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Institutes of Health (grant number P60 AA006420) awarded to MR. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. National Institutes of Health (grant number K99 AA026638) awarded to DK. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Austrian Fields of Science 2012

301406 Neuropharmacology
301206 Pharmacology
301210 Psychopharmacology

Keywords

Alcoholism/drug therapy
Amygdala/drug effects
Animals
Ethanol/metabolism
GABAergic Neurons/drug effects
Inhibitory Postsynaptic Potentials/physiology
Injections, Intraperitoneal
Male
Motivation/drug effects
Neurons/physiology
Oxytocin/metabolism
Patch-Clamp Techniques
Rats
Rats, Sprague-Dawley
Rats, Wistar
Synaptic Transmission/physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pbio.2006421Licence: Other

Cite this

Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., Leggio, L., Koob, G. F., Roberto, M., & Vendruscolo, L. F. (2019). Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biology, 17(4), Article e2006421. https://doi.org/10.1371/journal.pbio.2006421

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title = "Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala",

keywords = "Alcoholism/drug therapy, Amygdala/drug effects, Animals, Ethanol/metabolism, GABAergic Neurons/drug effects, Inhibitory Postsynaptic Potentials/physiology, Injections, Intraperitoneal, Male, Motivation/drug effects, Neurons/physiology, Oxytocin/metabolism, Patch-Clamp Techniques, Rats, Rats, Sprague-Dawley, Rats, Wistar, Synaptic Transmission/physiology",

author = "Tunstall, \{Brendan J\} and Dean Kirson and Zallar, \{Lia J\} and McConnell, \{Sam A\} and Vendruscolo, \{Janaina C M\} and Ho, \{Chelsea P\} and Oleata, \{Christopher S\} and Sophia Khom and Maurice Manning and Lee, \{Mary R\} and Lorenzo Leggio and Koob, \{George F\} and Marisa Roberto and Vendruscolo, \{Leandro F\}",

note = "Publisher Copyright: Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.",

year = "2019",

month = apr,

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doi = "10.1371/journal.pbio.2006421",

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Tunstall, BJ, Kirson, D, Zallar, LJ, McConnell, SA, Vendruscolo, JCM, Ho, CP, Oleata, CS, Khom, S, Manning, M, Lee, MR, Leggio, L, Koob, GF, Roberto, M & Vendruscolo, LF 2019, 'Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala', PLoS Biology, vol. 17, no. 4, e2006421. https://doi.org/10.1371/journal.pbio.2006421

TY - JOUR

T1 - Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

AU - Tunstall, Brendan J

AU - Kirson, Dean

AU - Zallar, Lia J

AU - McConnell, Sam A

AU - Vendruscolo, Janaina C M

AU - Ho, Chelsea P

AU - Oleata, Christopher S

AU - Khom, Sophia

AU - Manning, Maurice

AU - Lee, Mary R

AU - Leggio, Lorenzo

AU - Koob, George F

AU - Roberto, Marisa

AU - Vendruscolo, Leandro F

N1 - Publisher Copyright: Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

PY - 2019/4/16

Y1 - 2019/4/16

KW - Alcoholism/drug therapy

KW - Amygdala/drug effects

KW - Animals

KW - Ethanol/metabolism

KW - GABAergic Neurons/drug effects

KW - Inhibitory Postsynaptic Potentials/physiology

KW - Injections, Intraperitoneal

KW - Male

KW - Motivation/drug effects

KW - Neurons/physiology

KW - Oxytocin/metabolism

KW - Patch-Clamp Techniques

KW - Rats

KW - Rats, Sprague-Dawley

KW - Rats, Wistar

KW - Synaptic Transmission/physiology

UR - https://www.scopus.com/pages/publications/85064980691

U2 - 10.1371/journal.pbio.2006421

DO - 10.1371/journal.pbio.2006421

M3 - Article

C2 - 30990816

SN - 1544-9173

VL - 17

JO - PLoS Biology

JF - PLoS Biology

IS - 4

M1 - e2006421

ER -

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Funding

Austrian Fields of Science 2012

Keywords

UN SDGs

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