PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Yuan Ji; Marlieke G Veldhuis; Jantien Zandvoort; Fee L Romunde; Marien J C Houtman; Karen Duran; Gijs van Haaften; Eva-Maria Zangerl-Plessl; Hiroki Takanari; Anna Stary-Weinzinger; Marcel A G van der Heyden

doi:10.1186/s12929-017-0352-x

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

Yuan Ji
, Marlieke G Veldhuis
, Jantien Zandvoort
, Fee L Romunde
, Marien J C Houtman
, Karen Duran
, Gijs van Haaften
, Eva-Maria Zangerl-Plessl
, Hiroki Takanari
, Anna Stary-Weinzinger
, Marcel A G van der Heyden

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	44
Pages (from-to)	44
Number of pages	10
Journal	Journal of Biomedical Science
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s12929-017-0352-x
Publication status	Published - 15 Jul 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

301206 Pharmacology

Keywords

Journal Article
Drugs
POTASSIUM CHANNELS
Atrial fibrillation
Trafficking
K(IR)2.1
TRAFFICKING
I-K1
CHLOROQUINE
KCNJ2 MUTATION
ATRIAL-FIBRILLATION
SHORT-QT-SYNDROME
Short QT syndrome
HERG
ION-CHANNEL
ACTION-POTENTIAL CLAMP
LONG
PA-6
I
K 2.1

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10.1186/s12929-017-0352-xLicence: CC BY 4.0

http://phaidra.univie.ac.at/o:877012Licence: CC BY 4.0

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Ji, Y., Veldhuis, M. G., Zandvoort, J., Romunde, F. L., Houtman, M. J. C., Duran, K., van Haaften, G., Zangerl-Plessl, E.-M., Takanari, H., Stary-Weinzinger, A., & van der Heyden, M. A. G. (2017). PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. Journal of Biomedical Science, 24(1), 44. Article 44. https://doi.org/10.1186/s12929-017-0352-x

@article{6fd78b9425f641f7987968bb05b7c78f,

title = "PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression",

keywords = "Journal Article, Drugs, POTASSIUM CHANNELS, Atrial fibrillation, Trafficking, K(IR)2.1, TRAFFICKING, I-K1, CHLOROQUINE, KCNJ2 MUTATION, ATRIAL-FIBRILLATION, SHORT-QT-SYNDROME, Short QT syndrome, HERG, ION-CHANNEL, ACTION-POTENTIAL CLAMP, LONG, PA-6, I, K 2.1",

author = "Yuan Ji and Veldhuis, \{Marlieke G\} and Jantien Zandvoort and Romunde, \{Fee L\} and Houtman, \{Marien J C\} and Karen Duran and \{van Haaften\}, Gijs and Eva-Maria Zangerl-Plessl and Hiroki Takanari and Anna Stary-Weinzinger and \{van der Heyden\}, \{Marcel A G\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = jul,

day = "15",

doi = "10.1186/s12929-017-0352-x",

language = "English",

volume = "24",

pages = "44",

journal = "Journal of Biomedical Science",

issn = "1021-7770",

number = "1",

}

Ji, Y, Veldhuis, MG, Zandvoort, J, Romunde, FL, Houtman, MJC, Duran, K, van Haaften, G, Zangerl-Plessl, E-M, Takanari, H, Stary-Weinzinger, A & van der Heyden, MAG 2017, 'PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression', Journal of Biomedical Science, vol. 24, no. 1, 44, pp. 44. https://doi.org/10.1186/s12929-017-0352-x

TY - JOUR

T1 - PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

AU - Ji, Yuan

AU - Veldhuis, Marlieke G

AU - Zandvoort, Jantien

AU - Romunde, Fee L

AU - Houtman, Marien J C

AU - Duran, Karen

AU - van Haaften, Gijs

AU - Zangerl-Plessl, Eva-Maria

AU - Takanari, Hiroki

AU - Stary-Weinzinger, Anna

AU - van der Heyden, Marcel A G

PY - 2017/7/15

Y1 - 2017/7/15

KW - Journal Article

KW - Drugs

KW - POTASSIUM CHANNELS

KW - Atrial fibrillation

KW - Trafficking

KW - K(IR)2.1

KW - TRAFFICKING

KW - I-K1

KW - CHLOROQUINE

KW - KCNJ2 MUTATION

KW - ATRIAL-FIBRILLATION

KW - SHORT-QT-SYNDROME

KW - Short QT syndrome

KW - HERG

KW - ION-CHANNEL

KW - ACTION-POTENTIAL CLAMP

KW - LONG

KW - PA-6

KW - I

KW - K 2.1

UR - https://www.scopus.com/pages/publications/85024491506

U2 - 10.1186/s12929-017-0352-x

DO - 10.1186/s12929-017-0352-x

M3 - Article

C2 - 28711067

SN - 1021-7770

VL - 24

SP - 44

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

IS - 1

M1 - 44

ER -

PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression

UN SDGs

Austrian Fields of Science 2012

Keywords

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