Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum

Ulrike Grienke; Judit Mihaly-Bison; Daniela Schuster; Taras Afonyushkin; Markus Binder; Shu-hong Guan; Chun-ru Cheng; Gerhard Wolber; Hermann Stuppner; De-an Guo; Valery N. Bochkov; Judith M. Rollinger

doi:10.1016/j.bmc.2011.09.039

Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum

Ulrike Grienke
, Judit Mihaly-Bison
, Daniela Schuster
, Taras Afonyushkin
, Markus Binder
, Shu-hong Guan
, Chun-ru Cheng
, Gerhard Wolber
, Hermann Stuppner
, De-an Guo
, Valery N. Bochkov
, Judith M. Rollinger

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	6779-6791
Number of pages	13
Journal	Bioorganic & Medicinal Chemistry
Volume	19
Issue number	22
DOIs	https://doi.org/10.1016/j.bmc.2011.09.039
Publication status	Published - 15 Nov 2011
Externally published	Yes

Funding

This work was funded by the National Research Network (NFN)-project 'Drugs from Nature Targeting Inflammation' S10703/S10711/S10713 granted by the Austrian Science Fund (FWF). D. S. is grateful for a young talents grant and the Erika Cremer Habilitations Program from the University of Innsbruck.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Austrian Fields of Science 2012

104013 Natural product chemistry

Keywords

Farnesoid X receptor
Ganoderma lucidum
Lanostane triterpenes
Ganoderic acids
Molecular modeling
Virtual screening
Natural products
FARNESOID-X-RECEPTOR
BILE-ACID RECEPTOR
NATURAL-PRODUCT GUGGULSTERONE
ORPHAN NUCLEAR RECEPTOR
HYPERLIPIDEMIC RATS
GENE-EXPRESSION
MARINE SPONGE
POTENT
LIGAND
ACTIVATION

Access to Document

10.1016/j.bmc.2011.09.039

Cite this

Grienke, U., Mihaly-Bison, J., Schuster, D., Afonyushkin, T., Binder, M., Guan, S., Cheng, C., Wolber, G., Stuppner, H., Guo, D., Bochkov, V. N., & Rollinger, J. M. (2011). Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum. Bioorganic & Medicinal Chemistry, 19(22), 6779-6791. https://doi.org/10.1016/j.bmc.2011.09.039

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author = "Ulrike Grienke and Judit Mihaly-Bison and Daniela Schuster and Taras Afonyushkin and Markus Binder and Shu-hong Guan and Chun-ru Cheng and Gerhard Wolber and Hermann Stuppner and De-an Guo and Bochkov, \{Valery N.\} and Rollinger, \{Judith M.\}",

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doi = "10.1016/j.bmc.2011.09.039",

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Grienke, U, Mihaly-Bison, J, Schuster, D, Afonyushkin, T, Binder, M, Guan, S, Cheng, C, Wolber, G, Stuppner, H, Guo, D, Bochkov, VN & Rollinger, JM 2011, 'Pharmacophore-based discovery of FXR-agonists. Part II: Identification of bioactive triterpenes from Ganoderma lucidum', Bioorganic & Medicinal Chemistry, vol. 19, no. 22, pp. 6779-6791. https://doi.org/10.1016/j.bmc.2011.09.039

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AU - Grienke, Ulrike

AU - Mihaly-Bison, Judit

AU - Schuster, Daniela

AU - Afonyushkin, Taras

AU - Binder, Markus

AU - Guan, Shu-hong

AU - Cheng, Chun-ru

AU - Wolber, Gerhard

AU - Stuppner, Hermann

AU - Guo, De-an

AU - Bochkov, Valery N.

AU - Rollinger, Judith M.

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KW - Natural products

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KW - BILE-ACID RECEPTOR

KW - NATURAL-PRODUCT GUGGULSTERONE

KW - ORPHAN NUCLEAR RECEPTOR

KW - HYPERLIPIDEMIC RATS

KW - GENE-EXPRESSION

KW - MARINE SPONGE

KW - POTENT

KW - LIGAND

KW - ACTIVATION

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