Piperazic acid containing peptides produced by an endophytic Streptomyces sp. isolated from the medicinal plant Atropa belladonna

Paulina Bekiesch (Corresponding author), Martina Oberhofer, Christina Sykora, Ernst Urban, Sergey Zotchev

    Publications: Contribution to journalArticlePeer Reviewed

    Abstract

    The culture broth of endophytic Streptomyces sp. AB100, isolated from the shoots of medicinal plant Atropa belladonna (L.) was investigated for the presence of antibacterial compounds. After initial testing followed by bioactivity-guided fractionation, six new piperazic acid (PA)-containing congeners of two known peptides, JBIR-39 and JBIR-40, were identified by HR-MS/MS and NMR analyses. Only the dehydroxylated hexapeptidic derivatives with unusual incorporation of four PA moieties exhibited weak antibacterial activity against Gram-positive test organism Bacillus subtilis. A 16S rDNA-based phylogenetic tree of known Streptomyces spp. producing PA-containing hexapeptides isolated from different habitats and endophyte Streptomyces AB100 showed considerable diversity, suggesting that these metabolites may play an important environmental role beyond their antibacterial activity.
    Original languageEnglish
    Pages (from-to)1090-1096
    Number of pages7
    JournalNatural Product Research
    Volume35
    Issue number7
    Early online date13 Jul 2019
    DOIs
    Publication statusPublished - 2021

    Austrian Fields of Science 2012

    • 304005 Medical biotechnology

    Keywords

    • ANTIBIOTICS
    • JBIR-39
    • JBIR-40
    • Piperazic acid
    • SERINE CARBOXYPEPTIDASE INHIBITOR
    • Streptomyces
    • endophyte

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