Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity

Jelena Banfic; Anton A. Legin; Michael A. Jakupec; Mathea Sophia Galanski; Bernhard K. Keppler

doi:10.1002/ejic.201301282

Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity

Jelena Banfic, Anton A. Legin, Michael A. Jakupec, Mathea Sophia Galanski (Corresponding author), Bernhard K. Keppler

Department of Inorganic Chemistry

Publications: Contribution to journal › Article › Peer Reviewed

Abstract

Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear ( ¹H, ¹³C, ¹⁵N, and ¹⁹⁵Pt) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC ₅₀ values in the low micromolar range in CH1 and SW480 human cancer cells were found.

Original language	English
Pages (from-to)	484-492
Number of pages	9
Journal	European Journal of Inorganic Chemistry
Volume	2014
Issue number	3
DOIs	https://doi.org/10.1002/ejic.201301282
Publication status	Published - Jan 2014

Austrian Fields of Science 2012

104003 Inorganic chemistry
301305 Medical chemistry

Keywords

Platinum
Ferrocene
Antitumor agents
Cytotoxicity
Metallocenes
ANTICANCER ACTIVITY
DERIVATIVES

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ejic.201301282

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title = "Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity",

abstract = "Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear ( 1H, 13C, 15N, and 195Pt) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC 50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.",

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AU - Banfic, Jelena

AU - Legin, Anton A.

AU - Jakupec, Michael A.

AU - Galanski, Mathea Sophia

AU - Keppler, Bernhard K.

N1 - Accession Number: WOS:000329999400009

PY - 2014/1

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N2 - Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear ( 1H, 13C, 15N, and 195Pt) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC 50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.

AB - Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear ( 1H, 13C, 15N, and 195Pt) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC 50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.

KW - Platinum

KW - Ferrocene

KW - Antitumor agents

KW - Cytotoxicity

KW - Metallocenes

KW - ANTICANCER ACTIVITY

KW - DERIVATIVES

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JF - European Journal of Inorganic Chemistry

SN - 1434-1948

IS - 3

ER -

Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity

Abstract

Austrian Fields of Science 2012

Keywords

UN SDGs

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