Abstract
6-[18F]Fluorodopamine (6-[18F]FDA) proved valuable as a diagnostic tool for neuroendocrine and rare tumors, such as ganglioneuromas and pheochromocytomas, however, clinical application is still limited. So far, its radiosyntheses were impeded by the formation of side-products, low molar activity, multi-step reactions and the use of challenging precursors. Here, we describe a detailed enzymatic procedure for fast, simple and high yield synthesis of no carrier added 6-[18F]FDA from 6-[18F]FDOPA with high radiochemical yield of ~69 % and >95 % purity as determined by radio-HPLC and -TLC. The product formulation was stable and suitable for in vivo application.
Original language | English |
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Pages (from-to) | 189-197 |
Number of pages | 9 |
Journal | Nuclear Medicine and Biology |
Volume | 114-115 |
DOIs | |
Publication status | Published - 1 Nov 2022 |
Austrian Fields of Science 2012
- 104020 Radiochemistry
Keywords
- 6-FDOPA
- 6-fluorodopamine
- Enzymatic
- Fluorine-18
- Radiosynthesis
- Tyrosine decarboxylase