Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases

SB Zotchev, AV Stepanchikova, AP Sergeyko, BN Sobolev, DA Filimonov, VV Poroikov

    Publications: Contribution to journalArticlePeer Reviewed

    Original languageEnglish
    Pages (from-to)2077-2087
    Number of pages11
    JournalJournal of Medicinal Chemistry
    Volume49
    Issue number6
    DOIs
    Publication statusPublished - 23 Mar 2006

    Austrian Fields of Science 2012

    • 106005 Bioinformatics
    • 104013 Natural product chemistry
    • 106013 Genetics

    Keywords

    • BIOLOGICAL-ACTIVITY SPECTRA
    • COMPUTER-PREDICTION
    • COMPOUND LIBRARIES
    • DRUG DISCOVERY
    • BIOSYNTHESIS
    • ERYTHROMYCIN
    • CELLS
    • ANTIBIOTICS
    • ROXITHROMYCIN
    • CHANNEL

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