TY - CHAP
T1 - Resources for Chemical, Biological, and Structural Data on Natural Products
AU - Chen, Ya
AU - de Bruyn Kops, Christina
AU - Kirchmair, Johannes
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019
Y1 - 2019
N2 - Natural products from plants, marine life, animals, fungi, bacteria, and other organisms remain the most productive source of inspiration for small-molecule drug discovery. Today, a wealth of information on natural products that is particularly valuable to applications in cheminformatics is at our disposal. In this contribution, we provide a timely overview of relevant resources for measured chemical, biological, and structural data on natural products. In particular, we comment on the accessibility, scope, chemical space, and limitations of the individual data sources. The bottleneck of natural products remains the limited availability of material for testing. In this context, we analyze the number of natural products readily obtainable from commercial and other sources.
AB - Natural products from plants, marine life, animals, fungi, bacteria, and other organisms remain the most productive source of inspiration for small-molecule drug discovery. Today, a wealth of information on natural products that is particularly valuable to applications in cheminformatics is at our disposal. In this contribution, we provide a timely overview of relevant resources for measured chemical, biological, and structural data on natural products. In particular, we comment on the accessibility, scope, chemical space, and limitations of the individual data sources. The bottleneck of natural products remains the limited availability of material for testing. In this context, we analyze the number of natural products readily obtainable from commercial and other sources.
KW - Biological Products/chemistry
KW - Chemistry, Pharmaceutical
KW - Computational Biology
KW - Drug Discovery
KW - Cheminformatics
KW - Vendors
KW - Virtual screening
KW - Chemical space
KW - Databases
KW - Components of traditional medicines
KW - Natural products
KW - Drug discovery
KW - Readily obtainable natural products
UR - https://www.scopus.com/pages/publications/85073424527
U2 - 10.1007/978-3-030-14632-0_2
DO - 10.1007/978-3-030-14632-0_2
M3 - Chapter
C2 - 31621010
VL - 110
T3 - Progress in the Chemistry of Organic Natural Products
SP - 37
EP - 71
BT - Progress in the chemistry of organic natural products
ER -