TY - JOUR
T1 - Resveratrol, an Ingredient of Wine, Acts Synergistically with Ara-C and Tiazofurin in HL-60 Human Promyelocytic Leukemia Cells
AU - Horvath, Zsuzsanna
AU - Saiko, Philipp
AU - Illmer, Christoph
AU - Hoechtl, Thomas
AU - Bauer, Wolfgang
AU - Erker, Thomas
AU - Jäger, Walter
AU - Fritzer-Szekeres, Monika
AU - Szekeres, Thomas
N1 - 09.08.2007: Datenanforderung 1815 (Import Sachbearbeiter)
09.02.2010: Datenanforderung UNIVIS-DATEN-DAT.RA-2 (Import Sachbearbeiter)
PY - 2006
Y1 - 2006
N2 - Resveratrol (RV), a naturally occurring stilbene derivative, is a potent free radical scavenger causing a number of biochemical and antineoplastic effects. It was shown to induce differentiation and apoptosis in leukemia cells and was also identified as an inhibitor of ribonucleotide reductase (RR), a key enzyme of DNA synthesis. In this study, we report about the biochemical effects of RV in HL-60 human promyelocytic leukemia cells. RV effectively inhibited in situ RR activity. Furthermore, incubation of HL-60 cells with RV significantly decreased intracellular dCTP, dTTP, dATP and dGTP concentrations. In growth inhibition and clonogenic assays, RV acted synergistically with both Ara-C and tiazofurin in HL-60 cells. We conclude that RV could become a viable candidate as one compound in the combination chemotherapy of leukemia and therefore deserves further in vitro and in vivo testing. Copyright ΠTaylor & Francis Group, LLC.
AB - Resveratrol (RV), a naturally occurring stilbene derivative, is a potent free radical scavenger causing a number of biochemical and antineoplastic effects. It was shown to induce differentiation and apoptosis in leukemia cells and was also identified as an inhibitor of ribonucleotide reductase (RR), a key enzyme of DNA synthesis. In this study, we report about the biochemical effects of RV in HL-60 human promyelocytic leukemia cells. RV effectively inhibited in situ RR activity. Furthermore, incubation of HL-60 cells with RV significantly decreased intracellular dCTP, dTTP, dATP and dGTP concentrations. In growth inhibition and clonogenic assays, RV acted synergistically with both Ara-C and tiazofurin in HL-60 cells. We conclude that RV could become a viable candidate as one compound in the combination chemotherapy of leukemia and therefore deserves further in vitro and in vivo testing. Copyright ΠTaylor & Francis Group, LLC.
M3 - Article
SN - 1525-7770
VL - 25
SP - 1019
EP - 1024
JO - Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
JF - Nucleosides, Nucleotides and Nucleic Acids: an international journal for rapid communication
IS - 9-11
ER -