Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Maria V. Babak; Martin Pfaffeneder-Kmen; Samuel M. Meier-Menches; Maria S. Legina; Sarah Theiner; Cinthia Licona; Christophe Orvain; Michaela Hejl; Muhammad Hanif; Michael A. Jakupec; Bernhard K. Keppler; Christian Gaiddon; Christian G. Hartinger

doi:10.1021/acs.inorgchem.7b03210

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Maria V. Babak (Corresponding author)
, Martin Pfaffeneder-Kmen
, Samuel M. Meier-Menches
, Maria S. Legina
, Sarah Theiner
, Cinthia Licona
, Christophe Orvain
, Michaela Hejl
, Muhammad Hanif
, Michael A. Jakupec
, Bernhard K. Keppler
, Christian Gaiddon
, Christian G. Hartinger (Corresponding author)

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Pages (from-to)	2851-2864
Number of pages	14
Journal	Inorganic Chemistry
Volume	57
Issue number	5
DOIs	https://doi.org/10.1021/acs.inorgchem.7b03210
Publication status	Published - 5 Mar 2018

Funding

We thank COST actions CM1105 (short term scientific mission to M.V.B.) and BM1307, and the University of Vienna (travel award to M.V.B.) for financial support. This project was supported by the Centre National pour la Recherche Scientifique (CNRS, France; C.G.), ARC, Ligue contre le Cancer, European action. We thank Prof. Markus Galanski for providing Pt precursors.

Austrian Fields of Science 2012

104003 Inorganic chemistry

Keywords

SHOWING HIGH CYTOTOXICITY
CANCER-CELL LINES
ANTITUMOR-ACTIVITY
PALLADIUM COMPLEXES
DONOR LIGANDS
DNA-BINDING
ER STRESS
ORGANOPLATINUM(II) COMPLEXES
ENDOPLASMIC-RETICULUM
CRYSTAL-STRUCTURE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.inorgchem.7b03210

Cite this

Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C., & Hartinger, C. G. (2018). Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry, 57(5), 2851-2864. https://doi.org/10.1021/acs.inorgchem.7b03210

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title = "Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action",

keywords = "SHOWING HIGH CYTOTOXICITY, CANCER-CELL LINES, ANTITUMOR-ACTIVITY, PALLADIUM COMPLEXES, DONOR LIGANDS, DNA-BINDING, ER STRESS, ORGANOPLATINUM(II) COMPLEXES, ENDOPLASMIC-RETICULUM, CRYSTAL-STRUCTURE",

author = "Babak, \{Maria V.\} and Martin Pfaffeneder-Kmen and Meier-Menches, \{Samuel M.\} and Legina, \{Maria S.\} and Sarah Theiner and Cinthia Licona and Christophe Orvain and Michaela Hejl and Muhammad Hanif and Jakupec, \{Michael A.\} and Keppler, \{Bernhard K.\} and Christian Gaiddon and Hartinger, \{Christian G.\}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = mar,

day = "5",

doi = "10.1021/acs.inorgchem.7b03210",

language = "English",

volume = "57",

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journal = "Inorganic Chemistry",

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Babak, MV, Pfaffeneder-Kmen, M, Meier-Menches, SM, Legina, MS, Theiner, S, Licona, C, Orvain, C, Hejl, M, Hanif, M, Jakupec, MA , Keppler, BK, Gaiddon, C & Hartinger, CG 2018, 'Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action', Inorganic Chemistry, vol. 57, no. 5, pp. 2851-2864. https://doi.org/10.1021/acs.inorgchem.7b03210

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. / Babak, Maria V. (Corresponding author); Pfaffeneder-Kmen, Martin; Meier-Menches, Samuel M. et al.
In: Inorganic Chemistry, Vol. 57, No. 5, 05.03.2018, p. 2851-2864.

Publications: Contribution to journal › Article › Peer Reviewed

TY - JOUR

T1 - Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

AU - Babak, Maria V.

AU - Pfaffeneder-Kmen, Martin

AU - Meier-Menches, Samuel M.

AU - Legina, Maria S.

AU - Theiner, Sarah

AU - Licona, Cinthia

AU - Orvain, Christophe

AU - Hejl, Michaela

AU - Hanif, Muhammad

AU - Jakupec, Michael A.

AU - Keppler, Bernhard K.

AU - Gaiddon, Christian

AU - Hartinger, Christian G.

PY - 2018/3/5

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KW - CANCER-CELL LINES

KW - ANTITUMOR-ACTIVITY

KW - PALLADIUM COMPLEXES

KW - DONOR LIGANDS

KW - DNA-BINDING

KW - ER STRESS

KW - ORGANOPLATINUM(II) COMPLEXES

KW - ENDOPLASMIC-RETICULUM

KW - CRYSTAL-STRUCTURE

UR - https://www.scopus.com/pages/publications/85042905483

U2 - 10.1021/acs.inorgchem.7b03210

DO - 10.1021/acs.inorgchem.7b03210

M3 - Article

SN - 0020-1669

VL - 57

SP - 2851

EP - 2864

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 5

ER -

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Funding

Austrian Fields of Science 2012

Keywords

UN SDGs

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