@article{6f660383cc02482d8b279992fcb465aa,
title = "Serotonin transporter binding in the human brain after pharmacological challenge measured using PET and PET/MR",
keywords = "Bolus plus infusion, Neuroimaging, PET, Quantification, Serotonin transporter, [C]DASB, bolus plus infusion, [C-11]DASB, quantification, QUANTIFICATION, ATTENUATION CORRECTION, REUPTAKE INHIBITORS, INFUSION, BETA-CIT, C-11 DASB, OCCUPANCY, SPECT, neuroimaging, POSITRON-EMISSION-TOMOGRAPHY, serotonin transporter, BOLUS, [ C]DASB",
author = "Silberbauer, {Leo R.} and Gregor Gryglewski and Neydher Berroter{\'a}n-Infante and Lucas Rischka and Thomas Vanicek and Verena Pichler and Marius Hienert and Alexander Kautzky and Cecile Philippe and Godbersen, {Godber M.} and Chrysoula Vraka and James, {Gregory M.} and Wolfgang Wadsak and Markus Mitterhauser and Marcus Hacker and Siegfried Kasper and Andreas Hahn and Rupert Lanzenberger",
note = "Funding Information: This project was performed with the support of the Medical Imaging Cluster of the Medical University of Vienna and was funded partly through a research agreement between the Medical University of Vienna and the Siemens Healthcare GmbH. This work was supported by a grant from the Else Kr{\"o}ner-Fresenius-Stiftung (2014_A192) to RL. Further, RL and LS were recipients of the DOC fellowships of the Austrian Academy of Sciences at the Department of Psychiatry and Psychotherapy, Medical University of Vienna. This work was also supported by the Austrian Science Fund (FWF) grant number KLI 516 to RL. The funding sources had no further role in the study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Funding Information: Meyer, J. H., Wilson, A. A., Ginovart, N., Goulding, V., Hussey, D., Hood, K., et al. (2001). Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [(11)C]DASB PET imaging study. Am. J. Psychiatry 158, 1843–1849. doi: 10.1176/appi.ajp.158.11.1843 Meyer, J. H., Wilson, A. A., Sagrati, S., Hussey, D., Carella, A., Potter, W. Z., et al. (2004). Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am. J. Psychiatry 161, 826–835. doi: 10.1176/appi.ajp.161.5.826 Norgaard, M., Ganz, M., Svarer, C., Feng, L., Ichise, M., Lanzenberger, R., et al. (2019). Cerebral serotonin transporter measurements with [(11)C]DASB: a review on acquisition and preprocessing across 21 PET centres. J. Cereb. Blood Flow Metab. 39, 210–222. doi: 10.1177/0271678x18770107 Paterson, L. M., Kornum, B. R., Nutt, D. J., Pike, V. W., and Knudsen, G. M. (2013). 5-HT radioligands for human brain imaging with PET and SPECT. Med. Res. Rev. 33, 54–111. doi: 10.1002/med.20245 Rahmim, A., and Zaidi, H. (2008). PET versus SPECT: strengths, limitations and challenges. Nucl. Med. Commun. 29, 193–207. doi: 10.1097/MNM. 0b013e3282f3a515 Savli, M., Bauer, A., Mitterhauser, M., Ding, Y. S., Hahn, A., Kroll, T., et al. (2012). Normative database of the serotonergic system in healthy subjects using multi-tracer PET. Neuroimage 63, 447–459. doi: 10.1016/j.neuroimage.2012. 07.001 Sogaard, B., Mengel, H., Rao, N., and Larsen, F. (2005). The pharmacokinetics of escitalopram after oral and intravenous administration of single and multiple doses to healthy subjects. J. Clin. Pharmacol. 45, 1400–1406. doi: 10.1177/ 0091270005280860 Spies, M., Knudsen, G. M., Lanzenberger, R., and Kasper, S. (2015). The serotonin transporter in psychiatric disorders: insights from PET imaging. Lancet Psychiatry 2, 743–755. doi: 10.1016/s2215-0366(15)00232-1 Turkheimer, F. E., Selvaraj, S., Hinz, R., Murthy, V., Bhagwagar, Z., Grasby, P., et al. (2012). Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example. J. Cereb. Blood Flow Metab. 32, 70–80. doi: 10.1038/jcbfm.2011.108 Willeit, M., Praschak-Rieder, N., Neumeister, A., Pirker, W., Asenbaum, S., Vitouch, O., et al. (2000). [123I]-beta-CIT SPECT imaging shows reduced brain serotonin transporter availability in drug-free depressed patients with seasonal affective disorder. Biol. Psychiatry 47, 482–489. doi: 10.1016/s0006-3223(99) 00293-0 Conflict of Interest Statement: SK received the grants/research support, consulting fees, and/or honoraria within the last three years from the Angelini, AOP Orphan Pharmaceuticals AG, Celegne GmbH, Eli Lilly, Janssen-Cilag Pharma GmbH, KRKA-Pharma, Lundbeck A/S, Mundipharma, Neuraxpharm, Pfizer, Sanofi, Schwabe, Servier, Shire, Sumitomo Dainippon Pharma Co. Ltd., and Takeda. RL received the conference speaker honorarium within the last three years from the Shire and research support from the Siemens Healthcare. MHa received the consulting fees and/or honoraria from the Bayer Healthcare BMS, Eli Lilly, EZAG, GE Healthcare, Ipsen, ITM, Janssen, Roche, and Siemens Healthineers. WW declares to having received speaker honoraria from the GE Healthcare and research grants from the Ipsen Pharma, Eckert-Ziegler AG, Scintomics, and ITG; and working as a part time employee of CBmed Ltd. (Center for Biomarker Research in Medicine, Graz, Austria). Publisher Copyright: {\textcopyright} 2019 Silberbauer, Gryglewski, Berroter{\'a}n-Infante, Rischka, Vanicek, Pichler, Hienert, Kautzky, Philippe, Godbersen, Vraka, James, Wadsak, Mitterhauser, Hacker, Kasper, Hahn and Lanzenberger. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = jul,
day = "12",
doi = "10.3389/fnmol.2019.00172",
language = "English",
volume = "12",
journal = "Frontiers in molecular neuroscience",
issn = "1662-5099",
}