Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Chrysoula Vraka; Matej Murgaš; Lucas Rischka; Barbara Katharina Geist; Rupert Lanzenberger; Gregor Gryglewski; Thomas Zenz; Wolfgang Wadsak; Markus Mitterhauser; Marcus Hacker; Cécile Philippe; Verena Pichler

doi:10.1038/s41598-022-06906-0

Simultaneous radiomethylation of [¹¹C]harmine and [¹¹C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

Chrysoula Vraka
, Matej Murgaš
, Lucas Rischka
, Barbara Katharina Geist
, Rupert Lanzenberger
, Gregor Gryglewski
, Thomas Zenz
, Wolfgang Wadsak
, Markus Mitterhauser
, Marcus Hacker
, Cécile Philippe (Corresponding author)
, Verena Pichler

Publications: Contribution to journal › Article › Peer Reviewed

Original language	English
Article number	3283
Number of pages	12
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-06906-0
Publication status	Published - 28 Feb 2022

Funding

R. Lanzenberger received travel Grants and/or conference speaker honoraria within the last three years from Bruker BioSpin MR, Heel, and support from Siemens Healthcare regarding clinical research using PET/MR. He is a shareholder of the start-up company BM Health GmbH since 2019. Without relevance to this work, W. Wadsak declares that he is a part-time employee at CBmed GmbH, Graz, Austria, and co-founder of MINUTE medical GmbH, Vienna, Austria. All other authors declare that they have no conflict of interest. We kindly acknowledge the Medical Imaging Cluster (MIC) and thank Dr. Lalith Kumar Shiyam Sundar (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria) and Dr. Stefan Gruenert and the working group members Eva-Maria Klebermass, Karsten Bamminger and Marius Ozenil for fruitful discussions and proof reading of the manuscript, and Assoc. Prof. Andreas Hahn, Ph.D. for teaching basic data analyses of both radioligands. Furthermore, we would like to thank Ing. Andreas Krcal as radiation safety officer and for his technical support and assistance. PET data used for the simulations are provided from studies supported by the Austrian Science Fund (FWF, Grant Nos. KLI504 and P 27141, both awarded to R.L.). MMu is funded by the Austrian Science Fund FWF DOC 33-B27.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Austrian Fields of Science 2012

104020 Radiochemistry
104003 Inorganic chemistry

Keywords

ACQUISITION
BINDING
EMISSION-TOMOGRAPHY QUANTIFICATION
SEASONAL-VARIATION
TRANSPORTER
Neuroimaging
Brain/diagnostic imaging
Humans
Tomography, X-Ray Computed
Harmine
Positron-Emission Tomography/methods

Access to Document

10.1038/s41598-022-06906-0Licence: CC BY 4.0

https://phaidra.univie.ac.at/o:1660051Licence: CC BY 4.0

Cite this

Vraka, C., Murgaš, M., Rischka, L., Geist, B. K., Lanzenberger, R., Gryglewski, G., Zenz, T., Wadsak, W., Mitterhauser, M., Hacker, M., Philippe, C., & Pichler, V. (2022). Simultaneous radiomethylation of [¹¹C]harmine and [¹¹C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual. Scientific Reports, 12(1), Article 3283. https://doi.org/10.1038/s41598-022-06906-0

@article{589158eef92e4187a92a8a981107c03d,

title = "Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual",

keywords = "ACQUISITION, BINDING, EMISSION-TOMOGRAPHY QUANTIFICATION, SEASONAL-VARIATION, TRANSPORTER, Neuroimaging, Brain/diagnostic imaging, Humans, Tomography, X-Ray Computed, Harmine, Positron-Emission Tomography/methods",

author = "Chrysoula Vraka and Matej Murga{\v s} and Lucas Rischka and Geist, \{Barbara Katharina\} and Rupert Lanzenberger and Gregor Gryglewski and Thomas Zenz and Wolfgang Wadsak and Markus Mitterhauser and Marcus Hacker and C{\'e}cile Philippe and Verena Pichler",

note = "Funding Information: R. Lanzenberger received travel Grants and/or conference speaker honoraria within the last three years from Bruker BioSpin MR, Heel, and support from Siemens Healthcare regarding clinical research using PET/MR. He is a shareholder of the start-up company BM Health GmbH since 2019. Without relevance to this work, W. Wadsak declares that he is a part-time employee at CBmed GmbH, Graz, Austria, and co-founder of MINUTE medical GmbH, Vienna, Austria. All other authors declare that they have no conflict of interest. Funding Information: We kindly acknowledge the Medical Imaging Cluster (MIC) and thank Dr. Lalith Kumar Shiyam Sundar (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria) and Dr. Stefan Gruenert and the working group members Eva-Maria Klebermass, Karsten Bamminger and Marius Ozenil for fruitful discussions and proof reading of the manuscript, and Assoc. Prof. Andreas Hahn, Ph.D. for teaching basic data analyses of both radioligands. Furthermore, we would like to thank Ing. Andreas Krcal as radiation safety officer and for his technical support and assistance. Funding Information: PET data used for the simulations are provided from studies supported by the Austrian Science Fund (FWF, Grant Nos. KLI504 and P 27141, both awarded to R.L.). MMu is funded by the Austrian Science Fund FWF DOC 33-B27. Publisher Copyright: {\textcopyright} 2022, The Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.",

year = "2022",

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Vraka, C, Murgaš, M, Rischka, L, Geist, BK, Lanzenberger, R, Gryglewski, G, Zenz, T, Wadsak, W, Mitterhauser, M, Hacker, M, Philippe, C & Pichler, V 2022, 'Simultaneous radiomethylation of [¹¹C]harmine and [¹¹C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual', Scientific Reports, vol. 12, no. 1, 3283. https://doi.org/10.1038/s41598-022-06906-0

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T1 - Simultaneous radiomethylation of [11C]harmine and [11C]DASB and kinetic modeling approach for serotonergic brain imaging in the same individual

AU - Vraka, Chrysoula

AU - Murgaš, Matej

AU - Rischka, Lucas

AU - Geist, Barbara Katharina

AU - Lanzenberger, Rupert

AU - Gryglewski, Gregor

AU - Zenz, Thomas

AU - Wadsak, Wolfgang

AU - Mitterhauser, Markus

AU - Hacker, Marcus

AU - Philippe, Cécile

AU - Pichler, Verena

N1 - Funding Information: R. Lanzenberger received travel Grants and/or conference speaker honoraria within the last three years from Bruker BioSpin MR, Heel, and support from Siemens Healthcare regarding clinical research using PET/MR. He is a shareholder of the start-up company BM Health GmbH since 2019. Without relevance to this work, W. Wadsak declares that he is a part-time employee at CBmed GmbH, Graz, Austria, and co-founder of MINUTE medical GmbH, Vienna, Austria. All other authors declare that they have no conflict of interest. Funding Information: We kindly acknowledge the Medical Imaging Cluster (MIC) and thank Dr. Lalith Kumar Shiyam Sundar (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria) and Dr. Stefan Gruenert and the working group members Eva-Maria Klebermass, Karsten Bamminger and Marius Ozenil for fruitful discussions and proof reading of the manuscript, and Assoc. Prof. Andreas Hahn, Ph.D. for teaching basic data analyses of both radioligands. Furthermore, we would like to thank Ing. Andreas Krcal as radiation safety officer and for his technical support and assistance. Funding Information: PET data used for the simulations are provided from studies supported by the Austrian Science Fund (FWF, Grant Nos. KLI504 and P 27141, both awarded to R.L.). MMu is funded by the Austrian Science Fund FWF DOC 33-B27. Publisher Copyright: © 2022, The Author(s). Copyright: Copyright 2022 Elsevier B.V., All rights reserved.

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KW - EMISSION-TOMOGRAPHY QUANTIFICATION

KW - SEASONAL-VARIATION

KW - TRANSPORTER

KW - Neuroimaging

KW - Brain/diagnostic imaging

KW - Humans

KW - Tomography, X-Ray Computed

KW - Harmine

KW - Positron-Emission Tomography/methods

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